Nephropathy ¢ñ Plaster Treatment Of Chronic Nephritis Deficiency Syndrome 40 Cases Of Clinical Observation

Objective: To investigate the clinical effect and safety of Shenbing I plaster on the treatment of chronic glomerulonephritis of Yang-deficiency, and try to find out the mechanism of Shenbing I plaster through clinical experiment.Methods: 60 patients came from out-patient clinic (OPD) and hospitalization with CGN of Yang-deficiency were selected and randomly divided into three groups: a acupoint sticking therapeutic/treatment group(treated with Shenbing I plaster), a local sticking treatment group and a control group (only treated with western medicine such as nifedipine 10mg/per day ). 20 patients for each group .All the patients in each group were not significantly different on sex , age, course and the grade level of renal function, we observed on the/their symptoms and signs pre-treatment and post-treatment . Blood-routine, urine-routine, stool-routine, hepatic function and renal function were determined to evaluate the reliability before and after the treatment. Creatinine clearance(Ccr), 3h erythrocyte counts, Immunoglobulin(Ig), Complement(C), Tch, TG, Fibrinogen(Fib) were also measured to evaluate the effect of Shenbing I plaster.Results: After the treatment, Group A decreased significantly in 24 h urineprotein quantity, urea, Scr, BUN, total cholesterol, triglyceride, fibrinogen and CD// CD8+, and increased in IgG, IgA and Ccr, Scr, total cholesterol IgG in group Atreated with Shenbing I plaster decreased significantly, and Ccr, CD4+ / CD8+increased obviously in group A compared with other two groups.Conclusion: The symptoms and signs of the patients in group A and B were better after the treatment. There was no significant difference in statistics, but from the data we can see that the total effective rate of group A were better than group B and C. Shenbing I plaster has significant clinical effect in the treatment on CGN of YANG-deficiency. It could effectively alleviate the symptoms and signs without obvious toxicity and ill-effect. Shenbing I plaster could decrease hematuria, proteinuria and blood-lipid, regulate immunological function of the patients with chronic glomerulonephritis, improve their renal function and prevent their renal function to get worse further. The mechanism of Shenbing I plaster in the treatment on CGN of Yang -deficiency may be lie in: through dilating extra-vessels, decreasing blood pressure and blood-lipid, improving blood stream of the kidney, reducing the abnormal distribution of extracellular matrix(ECM), regulating immunity function, postponing or preventing the occurent of renal failure.