| Vascular Dementia is one of the senile dementia ' principal forms, is the gained mental impairment syndrome caused by a series of cerebrovascular factors such as ischemia or haemorrhage leading to brain tissue impairment. In ancient literature it was explained for "dai", "chi", "dian"ect. This article put forward the mechanism of the disease which is deficient of the liver and kidney being root cause, phlegm stagnation obstructing meridian being symptoms and apple the TCM basic theory to analyse on basis of reviewing VD's chinese and western medicine etiology and pathogenesis and therapy. At same time this article set forth VD's TCM symptoms and signs distinetive feature and positive that replenishing kidney and liver, promote blood circulation and remove blood stasis, strengthening brain and nourishing mentality is an effective method in treating VD.In the part of clinical study we adopt DSM-Ⅳ,MMSE,ADL,BBS and TCM syndrome differentiation standard and choose 48 cases who take part in this study freely and conforming with the observation criteria. 48 cases are randomly divided into two groups. The treating method adopt double-blind and double-simulator.24 cases in treated group take CSC 4 capsules each time three times a day orally and simulated hydergine 2 tablets each time three times a day orally.24 cases in control group take hydergine 2 tablets each time episode and the states of tongue and pulse are recorded every month. Before treatment and after treatment complexion, lips,body type, pathologic symptom and electroencephalogram are recorded meanwhile safety parameters are abserved. To abserve the effect of every parameter in two groups and ca three times a day orally and simulated CSC 4 capsules each time three times a day orally. Taking medicine continues 12 weeks and follow-up is one time every month. Before taking medicine and after taking medicine MMSE,ADL, BBS ,TCM rry on statistical analysis, especially abserve MMSE, TCM episode and electroencephalogram.In evaluation of the therapeutic efficiency and safety analysis, 42cases had finished the clinical test according to plan (the treated group 23 cases, the control group 19 cases), one case in the treated group and 5 cases in the control group had been dropped off.MMSE effectiveness: in the treated group the control excellent rate reached 17.39% and the total effective rate reached 69.57%, in the control group the control excellent rate reached 15.79% and the total effective rate reached 52.63%. To analyse the results of therapyof two groups, there was no statistically difference. According to MMSE in before and after treatment's assessing, in the treated group the tendentious heal rate reached 65.22%,the turn-round rate reached 21.74%,the control rate reached 13.04%,the deteriorate rate reached 0.00% and in the control group the tendentious heal rate reached 33.33%,the turn-round rate reached 14.29%,the control rate reached 52.38%,the deteriorate rate reached 0.00%. The treated group's effectiveness in MMSE advantage over the control group's effectiveness in MMSE through statistical analysis(P<0.05).BBS effectiveness: in the treated group the control excellent rate reached 17.39% and the total effective rate reached 69.57%, in the control group the control excellent rate reached 5.26% and the total effective rate reached 42.11%. To analysis the results of therapy of two groups, there was no statistically difference. The treated group's effectiveness in behavior ability advantage over the control group's effectiveness in behavior ability through statistical analysis(P<0.05).ADL effectiveness: in the treated group the control excellent rate reached 4.35% and the total effective rate reached 43.48%, in the control group the control excellent rate reached 5.26% and the total effective rate reached 31.58%. To analysis the results of therapy of two groups, there was no statistically difference.TCM episode effectiveness: in the treated group the control excellent rate reached 34.78% and the total effective rate reached 78.26%, in... |
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