The Clinical Study And The Influence Of The Treatment Of Kidney-invigorating And Blood-promoting And Phlegm-dissipating To The VD Mice On The Expression Of NGB MRNA, Etc

Objective:_Manifests through the utilization invigorates the kidney the blood circulation phlegm reduction law treatment vascular Dementia mental the Naolisu capsule to pour into the observation which again to the ischemia mouse's experimental study and the clinical VD case treat,discusses this law prevention VD action mechanism and the clinical curative effect.Methods:Experimental study:Uses ties up the mouse two-sided arteria carotis communis anterior to block the blood stream, the preparation repeatedly repeatedly ischemia pours into the model again, after making the mold succeeds, divides into sham-operated group, model group, high-dose of Naolisu capsule group, low-dose of Naolisu capsule group and Hydergine group 5 groups, gives the medicine 15 days continuously, after the treatment had ended, the execution mouse beheads takes the brain, the influence which and the brain organization seahorse area brain red protein (NGB)mRNA expression sound the determination mice brain organization seahorse cell multiplication and perishes weakly.Clinical observation:Collects 30 examples to conform to the VD research standard patient, divides into the treatment group and the control group each 15 examples observation stochastically. The control group takes orally is Hydergine piece, the treatment group takes orally the Hydergine piece and Naolisu capsule. Around the observation and to two group of patient's clinical curative effects, the treatment the daily life ability's evaluation and the security carries on the comparison, statistics analysis and the appraisal.Results:Experimental study:The ischemia pours into the mouse after to filling again clothing the Naolisu treats, flows the type cell technique examination model group mice seahorse cell multiplication index and weak perishing rate obviously reduces; And is most obvious by the low-dose of Naolisu capsule group., each medication group is lower than the model group; The model group mice brain organization seahorse area NGB mRNA expression compares the sham-operated group to increase, each medication group compares the model group to increase. Clinical observation:1. Clinical curative effect comparison:The treatment group 15 examples, clinical control 2 examples, shows results 5 examples, effective 7 examples, invalid 1 example, total effectiveness 93.3%; The control group 15 examples, clinical control 1 example, shows results 4 examples, effective 7 examples, invalid 3 examples, total effectiveness 80.0%; The total effectiveness has the significance difference (p<0.05); the treatment group curative effect surpasses the control group.2. Around two groups treat utilize the mini-mental state examination table(MMSE) and Activities of Daily Living(ADL), the group quite prompts:the treatment group surpasses the control group.Conclusion:Observes the confirmation the Naolisu capsule through the clinical case to have the very good curative effect stupidly to Vascular Dementia. The experiment confirmed that t the Naolisu capsule takes the treatment Vascular Dementia stupid effective side medicinal preparation, the Naolisu has the obvious therapeutic action to the VD stupid mice, its action mechanism possibly is suppresses the seahorse cell to multiply excessively and to perish weakly; As well as the adjustment seahorse organizes NGBmRNA the expression, reduces the ischemia to pour into the damage again.