Coronary Syndromes Elements - On The Toxin's Role In Coronary Heart Disease

Purpose: Some statistics methods such as frequency,the decision- tree and neural-network are applied in this experiment to design questionnaire. The questionnaire of syndrome-factor, syndrome–character and syndrome- pathogenesis evolution of coronary heart disease inquired clinic experts to establish Three-dimensional structural database correlatively among. Used such as frequency,the decision tree and neural network and so on to define evaluation standards of syndrome-factor to conclude mainly syndrome-factors. the results that Toxico-Pathogentic Factor exist in four-stages in CHD from beginning to end, And Toxico-Pathogentic Factor take role in CHD in different stages reflect with relations with different syndrome. There are lots of theory and science data, which provide a new method that Toxico-Pathogentic Factor utilized in other diseases research.Material and method:According to the State republic standards, browse and abstract lots of articles relatively from past to present. subject to consult clinical experts, conclusion rule of syndrome-factor, syndrome-character, and syndrome pathogenesis evolution of CHD, which base on theory of modern psychological measurement and the introduction of the structured decision- making to apply scale learn method .Subject to clinical character of CHD, we form system of clinical index which design and establish clinical experts questionnaires of syndrome–factor, syndrome-character, and syndrome pathogenesis evolution rule. Content of item in scale learn and expression method are judged. the item are revised, increased and decreased and adjusted several times by using Delphi way to ensure item contents of questionnaires consistence with clinical character and syndrome, meanwhile reliability and validity questionnaires are evaluated excellent, so we finish framework and contents of questionnaires. there are 1218 clinical experts in 6 different of areas of China that is Northeast ,Northwest, North ,Southwest, south of China involve survey questionnaires ,which entry and check to establish three-dimension structural correlation database(in short expert questionnaires database).we utilize frequency and decisions-tree and neural net and statistic so on to analysis database.Results:1. Mainly disease syndrome factor of coronary heart disease in the four-stages of frequency results: Toxico-Pathogentic Factor in four phases(early onset period ,paroxysm period, remission period, recovery period) frequency distribution follows: recovery period)frequency distribution separately as follows: 39%,84%,56%,36%.Gradually increased frequency in earl and paroxysm period,and general Equilibrium decline in remission and recovery Period,show the changes the development trend from vigorous to failure.2.Relationship of major coronary heart disease syndrome and syndrome factor by statistic result shows: Syndrome factor of the Toxico-Pathogentic Factor in the early onset period of Qi and Yin deficiency syndrome ,Qi stagnancy and phlegm resistance syndrome .In the Paroxysm Period of Yang malaise heart syndrome,Cold coagulation heart vessel syndrome,Blood stasis Yang syndrome,Qi stagnancy and phlegm resistance syndrome .In the remission Period of cardiopulmonary Qi deficiency syndrome,Liver and spleen no coordination syndrome,Heart kidney Yang syndrome,in the recovery Period of Heart Qi deficiency syndrome,Qi and Yin deficiency syndrome,Yang,Qi stagnancy and cold ,the frequency distribution in between 22.41%一100.00%: on the contrary, different the syndromes in stages of Toxico-Pathogentic Factor ,in which frequency distributes in 12.15%一61.57%between.Gradually increased frequency in early and Paroxysm Period,and general equilibrium decline. In remission and recovery Period,show the enhances the development trend from vigorous to failure.3. Results of the decision tree show that The judgment rules of Coronary heart syndrome Mainly factors of Toxico-Pathogentic Factor in the four stages Of coronary heart disease(early onset period,paroxysm period,remission period, Recovery period),neural network training,the forecast of effect is consistent with that,whether training sets or set of evaluation,test sets accuracy reached over 62%.Conclusion:1 Questionnaires Design: According to guiding of Chinese Traditional Medicine theory, we connection with clinical character of CHD and browse lots of articles form past to present. Clinical character of CHD regard to survey object, which apply modern psychological measurement theory into structured decision-making to form experts questionnaires of syndromes-factor, syndromes-characters, and syndrome pathogenesis evolution rule. Toxico-Pathogentic Factor are analyzed by mathematics statistic method, the results reflect Toxico-Pathogentic syndromes-characters inFour- phases of CHD. Toxico-Pathogentic Factor is applied in CHD that is valuable, which provide a new research method applied in others diseases.2 Questionnaires survey: structures and contents of questionnaires to be revised better by Delphi way. Reliability and validity questionnaires are evaluated excellent, we perform to practice, and the method is easy to operate. The survey of other diseases tries to apply it.3 Syndrome-factor. Frequency show Toxico-Pathogentic Factor in early onset period of CHD , Toxico-Pathogentic Factor exist seldom and recovery period remission period of CHD, Toxico-Pathogentic Factor occupy little ,because treatment demission toxics. Paroxysm period, and remission period, Toxico-Pathogentic Factor increase trend, because Toxico-Pathogentic increase results. Decesion-tree and neural net take important role in Toxico-Pathogentic Factor survey.4 Symptoms distribution .The statistical method of frequency of distribution is applied in survey questionnaires. The item of four phases of CHD are applied in histogram by frequency distribution, which connect with TCM pathogenesis theory to analyze each variable changing in early onset period ,paroxysm period, remission period, recovery period of CHD. The results show that most of variable appear in early onset period and paroxysm period. During paroxysm period that variable is heaviest. Generally variable decline trend in remission period, recovery period that extent lighter. Frequency of distribution reflects clinical symptoms of CHD basically .In order to induce syndrome-factor, frequency of distribution provides data support and theory.5 We analysis different groups of syndromes and tongues and plus in 4 stages (early onset period, paroxysm period, remission period, recovery period) to look for kind of syndrome and syndrome-factor of CHD .We find that Toxico-Pathogentic Factor takes important role in Coronary Heart Disease attacked four stages.