The Relationship Between The Expression Of Growth Differentiation Factor-15 In Serum And Coronary Heart Disease

Objective:This study was to detect growth differentiation factor-15 (growth differentiation factor-15, GDF-15) levels in coronary heart disease (coronary heart disease, CHD) patients, discussion the relationship between GDF-15 and coronary artery lesions and plaque stability, analysis the identification and significance that GDF-15 to acute coronary syndrome (acute coronary syndrome, ACS) Further.Method:To meet the criteria for 80 cases,60 patients in CHD group that included 28 patients with stable CHD patients with angina pectoris (stable angina pectoris, SAP) patients and 32 patients with ACS patients and 20 patients without coronary heart disease (non-coronary heart disease, NC) as control group; collected clinical data for all subjects and coronary angiography (coronary angiography, CAG) results; detected serum levels of GDF-15 by Double-antibody sandwich ELISA; compared the serum levels of GDF-15 in different groups; observed the relationship between GDF-15 and CAG in ACS group; discussed the correlation between the of GDF-15 to the clinical variables in patients with CHD.Result:1. There were no statistically significant differences on age, sex, BMI, smoking, overweight, family history of premature coronary heart disease, dyslipidemia, hypertension, diabetes, TC, TG, HDL-C, LDL-C, ApoAl, ApoB, GLU, Cr, SBP, DBP in ACS Group, SAP group and the NC groups (p>0.05); hs-CRP levels were significantly higher than that of ACS SAP group, NC group, the difference was statistically significant (p<0.001), and those of SAP group was significantly higher than that of NC group, the difference was statistically significant (p<0.001).2. The GDF-15 serum levels in CHD group were significantly higher than that of NC group, the difference was statistically significant (p<0.01).3. The GDF-15 serum levels in ACS group were significantly higher than that of the SAP group and NC group,the differences was statistically significant (p<0.01); the GDF-15 serum levels in SAP group were higher than that of the NC group, the difference was statistically significant (p<0.05).4. The GDF-15 serum levels were positively correlated with vascular disease count, Gensini points in ACS group.5. The expression of GDF-15 was positive correlated with the history of dyslipidemia, TG, GLU, hs-CRP in CHD group.Conclusion:1. The expression of GDF-15 is closely associated with the incidence and the progress of CHD, the increasing of expression of GDF-15 may suggest severity of coronary lesions.2. The expression of GDF-15 may be related to the stability of atherosclerotic plaques, the increasing of expression of GDF-15 may suggest the increasing of instability plaque, high incidence of acute coronary events. These suggest that GDF-15 may be an observation as a risk factors for ACS.3. In patients with CHD, the expression of GDF-15 was positive correlated with the history of dyslipidemia, TG, GLU, hs-CRP.Keyword:Growth differentiation factor 15; coronary heart disease; stable angina pectoris; acute coronary syndrome...