Vdac-1,α-enolase,sod2 And Gstp2 Make Sense In Fd Models Treated By The Chinese Medicine

Functional dyspepsia (FD), according to the'RomeⅢ'Consensus Report, is defined by 12 wk in the past 12 mo, of persistent or recurrent pain or discomfort in the upper abdomen, in the absence of organic disease and no association with bowel habit. There are three types of the FD, which is Weakness of the spleen and the stomach type, Liver-stomach disharmonyc type, splenogastric hygropyrexia type. The pathogenesis of Functional Dyspepsia (FD) remains unclear, motor dysfunction of upper gastrointestinal, drink and food, psychological and society would be possible relevant. Especially, research has demonstrated an association between this common diagnosis and psychosocial factors. Now the challenge is how to elucidate the pharmaceutic mechanisms of"Wei Kangning", which will greatly benefit the development of traditional Chinese medicines for prevention and therapy of FD.Preliminary work has already identified the target spots from functional dyspepsia by two-dimensional electrophoresis (2DE), mass spectrometry, such as VDAC-1,α-enolase, SOD2, GSTP2. We will use fluorescence quantitative PCR technology and western blotting to test them. The information provided here, therefore, in order to further study, we will deepen our knowledge on how"Wei Kangning"is against the Functional dyspepsia.