Research Of Factors For Motor Complications Of Parkinson's Disease

Objective : Explorling the factors for motor complications of Parkinson's disease,in order to search out the main factors affecting the appearance of complications, and find method to prevent or delay the motor complications in clinical use.Methods: We collected the information of 98 cases of confirmed PD,including gender,age,onset age,smoking history,course of disease,first symptoms,average daily dose of LD,treatment time of LD,whether use of any other anti-PD drugs and the type of drug, whether had a motor complication and the type.Then had H-Y classification and Webster score for them. Using univariate logistic regression to analyse the above factors,and selecting the factors with the P<0.1 for the non-conditional logistic regression analysis , to look for the factors associated with motor complications of Parkinson's disease.Results: The result of univariate logistic regression shows that onset age,smoking history,course of disease,H-Y classification,Webster score,average daily dose of LD,treatment time of LD are associated with the appearance of motor complications (P<0.1). Used non-conditional logistic regression to analyse the above factors and found that the onset age,course of disease,H-Y classification, average daily dose of LD,treatment time of LD are related in the motor complications(P<0.05),in which age of onset is protective factor (β<0) and course of disease,H-Y classification,average daily dose of LD,treatment time of LD are risk factors(β>0).The order according to their degree of risk is treatment time of LD,course of disease,average daily dose of LD,H-Y classification. Picking out the data of male patients for univariate logistic regression shows that smoking is associated with the occurrence of motor complications in male patients (P<0.05),and is the protective factor(β<0).Conclusion: Motor complications of PD is affected by onset age,course of disease,H-Y classification,average daily dose of LD,treatment time of LD,including onset age is a protective factor,course of disease,H-Y classification, average daily dose of LD,treatment time of LD,are risk factors. The order according to their degree of risk is treatment time of LD,course of disease,average daily dose of LD,H-Y classification. Thus,In the clinical course of treatment we should consider the different condition of each patient with related factors and select the best treatment,on the purpose of controling symptoms,slowing down the development of disease,prevening and reducing the complications caused by drug.