The Clinical Features And Analysis Of Risk Factors Of Parkinson’s Disease With Chronic Pain

Objective:1.To investigate the clinical features of Parkinson’s disease patients with chronic pain,including prevalence,type of chronic pain,type number of chronic pain,and time of occurrence of pain;2.Analysis of risk factors for PD with chronic pain.Methors:The demographic information and clinical data of 105 patients with primary PD were collected,and the subjects were required to have a pain course of 3 months or more.The collected information includes: age,gender,height,weight,education level,duration of disease,body side where first symptoms appear,levodopa equivalent daily dose(LEDD),medical conditions predisposing to pain,and cognition(MMSE),anxiety(HARS),depression(HDRS),sleep quality(PSQI).Evaluate the basic features of Parkinson’s disease and calculate the non-motor symptoms score(Part I),daily life activity ability score(Part II),motor ability score(Part III),and motor complications score(Part IV)of the Unified Parkinson Disease Rating.VAS(Visual Analogue Scale)assesses the severity of PD pain.According to VAS score,PD patients were divided into pain group(score≥1)and pain free group(score=0).Univariate and multivariate binary logistic regression models were used to examine the association between pain and study variables to predict risk factors for chronic pain of PD.Results:1.65 patients(61.9%)reported pain,and Musculoskeletal pain(41,63.1%)was the most common type of pain;of the 10 patients(15.4%),both types coexisted;12patients(18.5%)occurs pain before the onset of motor symptoms.2.Multivariate binary logistic regression analysis showed that: after controlling for confounding factors,sleep quality(OR=3.517,95%CI 1.225-10.102),medical conditions predisposing to pain(OR=4.612,95%CI 1.720-12.367),and motor complications(OR=7.923,95%CI 1.420-44.201)are risk factors for PD pain.Conclusion:1.The prevalence of pain in PD is very high,reaching 61.9%,and it contains a variety of pain types,and musculoskeletal pain is the most common type of pain in PD.Most patients have only one type of pain,and most patients experience pain after the onset of motor symptoms.2.Sleep quality,medical conditions predisposing to pain,and motor complications are risk factors for PD with chronic pain.