| Objective:To describe the status of HIV/AIDS knowledge and attitude among students in an Medical College in Hunan Province, and to analyze the determinants of the knowledge and attitude to HIV/AIDS in such population as well as to provide the scientific evidence on promoting the pertinent school health education for HIV/AIDS.Methods:the cross-sectional study with the stratified cluster sampling method was conducted to interview the medical students in grade one and grade two coming from the major of the nursing, health promotion, clinical medicine and pharmacy in an medical college in Hunan province with questionnaire which included 10 knowledge questions and 3 attitude questions. The rates of correctness, the rate of negative attitude, and the awareness rate were used to describe the status of the knowledge and attitude to HIV/AIDS. The univariate and multiple logistic regressions analysis were used to analyze the association between HIV/AIDS knowledge and attitude and gender, major, level, and grade. All statistical analysis were performed with SPSS version 15.0 and the two-side significant test level was set up as a=0.05.Results:a total of 3681 students finished the questionnaires. The correctness rate of knowledge question were ranged from 58.7% to 92.3%, respectively, and the total awareness rate was 74.4%, and the question of the lowest rate of correctness was'Can the risk of HIV/AIDS reduce if only one makes love with the uninfectious loyal partner?'. The rate of negative attitude were ranged from 7.5% to 11.8%, respectively, and the question of the highest rate of negative attitude was'Do you want to communicate with your friends or relatives who have AIDS?' Controlling by female, pharmacy students, college students, grade two students, the results of the univariate logistic regression of knowledge and attitude regarding to HIV/AIDS showed that male's knowledge rates of correctness were higher than female in 3 questions (P<0.05) and there no significant difference of the attitude by gender, the awareness rates of clinical medical students in 7 knowledge questions were higher than others (P<0.01), and the attitudes were nearly the same among all the majors, the rates of occupational middle school students in 4 knowledge questions and the awareness rate were lower than junior college students (P<0.05), and the attitude tended negatively in 2 attitude questions(P<0.01), the rates of grade one students in 4 knowledge questions and the awareness rate were higher than grade two (P<0.05), and the attitude tended negatively in 1 attitude question (P<0.01). The findings from multiple logistic regression analysis showed that the knowledge toward HIV/AIDS were associated with the gender (OR=1.18,95%CI 1.10,1.27), nursing major (OR=1.19,95%CI 1.11,1.27), health promotion (OR=0.41 95%CI 0.37,0.45), clinical medicine (OR=1.15,95%CI 1.06,1.24), level (OR=0.72,95%CI 0.69-0.76) and grade (OR=1.11,95%CI 1.16,1.28) and only level (OR=0.75,95%CI 0.66,0.86) related to the attitude of HIV/AIDS.Conclusion:1. The correctness rates of the questions on 3 kinds of transmission regarding to HIV/AIDS were higher than the non-transmission, and lower level sexual knowledge knew by the female students;2. The determinants of knowledge regarding to HIV/AIDS were gender, major, grade and level, so female students, occupational middle school students, students in some major were the main population to make the HIV/AIDS health education more permanent and effective;3. More than 10% students had the negative attitude toward AIDS patients, especially the occupational middle school students whose awareness rate was lower, so it was the crucial content that to change their attitude.
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