| Objective: The clinical data of 201 cases of GBS retrospective analysis to explore the clinical features of the disease and IVIG, PE, CS treatment, etc., so as to early diagnosis and proper handling of help.Materials and Methods:Retrospective analysis in January 1995 - January 2010 our department treated a clear diagnosis of GBS 201 hospital patients, are in line with Chinese Journal of Psychiatry 1993 Editorial Board of the development of GBS diagnostic criteria. According to EMG results were divided into groups axonal damage and demyelination injury group were compared certain clinical features and efficacy. The condition of patients were divided into light, medium and heavy; according to the different treatments of plasma exchange in the treatment group is divided into immune globulin treatment group, hormone therapy group; 2 weeks according to clinical recovery after treatment markedly divided into effective and ineffective group, compared under the same conditions the efficacy of different treatment groups; given different treatment, the incidence of the disease there is no difference to improve the time; immune globulin treatment group, hormone treatment, the time before and prognosis.Results: 201 patients, male 67.16%, female 32.84%. Age of onset is 15 to 44 years more than most summer disease, precursor to the upper respiratory tract infection by many factors accounted for 64.18%. 95.0% of patients with movement disorders, average onset 8±5.40 days for her to peak condition. Initial symptoms often physically unable to 48.26%, tendon reflexes and accounted for 75.12 percent, 55.72 percent of the patients had sensory dysfunction, 52.74% of patients had brain damage, 43.28% of the patients the performance of autonomic nerve damage, 28.86% involved the respiratory muscles , 13.43% of patients required endotracheal intubation or tracheostomy. There protein in cerebrospinal fluid - cell dissociation accounted for 96.41%, 87.80% of the patients with abnormal nerve conduction test results. Axonal damage group diarrhea was more (P <0.05), while more than a sense of multi-demyelinating group (P <0.05), were statistically significant; axonal damage and demyelination group showed no statistical effect of group school differences (P> 0.05). Immune globulin group and the plasma exchange group, under the same conditions there was no significant difference in efficacy (P> 0.05), at different treatment time for immune globulin or plasma exchange, were found P <0.05, the earlier the treatment, the more effective Well, there are statistically significant. For patients with mild or moderate disease, hormonal and immune globulin were significantly different efficiency (P <0.05); for heavy patients, hormone and immune globulin effective differentiated (P <0.05); for medium-sized patients, hormone and immune efficiency globulin no difference (P> 0.05). Plasma exchange group and the incidence of immune globulin group time to symptom improvement was no significant difference (P> 0.05), were significantly higher than the hormone group (P <0.05).Conclusion: The group of 201 cases of GBS patients with various clinical manifestations, cerebrospinal fluid and nerve electrophysiological test results consistent with the basic and domestic literature. Given immune globulin, plasma exchange treatment were significantly better efficacy, may shorten the course, and the earlier the treatment, the better the prognosis. Efficacy of immunoglobulin was significantly higher than hormones, hormones and general treatment now that the non-discrimination, and hormonal effects in the treatment of patients with GBS, GBS may be self-limiting disease caused by a natural outcome. |
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