Clinical Features And Treatment Analysis Of Guillain-Barre Syndrome

Objective:By analyzing the general data,clinical features,biochemical indexes,electromyography types of patients with mild or severe Guillain-Barre syndrome to summarize the factors that may predict the severity of the disease and compare the therapeutic effect in two groups.Methods:Retrospective collection of general data,clinical features,biochemical indexes,electromyography type and treatment of 94 GBS patients admitted and diagnosed between January 2015 and December 2019 in Department of Neurology,First Affiliated Hospital of Guangxi Medical University.They were divided into mild group(Hughes score ≤2)or severe group(Hughes score ≥3)according to Hughes score.Statistical analysis were applied to the data.Results:A total of 94 GBS patients,63 males and 31 females were collected in this study.There were 25 cases in the mild group(26.6%),and 69 cases in the severe group(73.4%).The proportion of patients in the severe group with age >50 and autonomic nerve involvement were significantly higher than that in the mild group(p<0.05).The CSF immunoglobulin concentration,neutrophil lymphocyte ratio and albumin index in the severe group were significantly higher than those in the mild group(p<0.05).Multivariate logistic regression analysis showed that age >50 years(p =0.013,OR =4.009,95% CI:1.342-11.977)and autonomic involvement(p =0.033,OR =4.086,95% CI =1.118-14.932)were independent risk factors for GBS.There was no significant difference between the mild and severe groups in terms of sex,onset season,course of disease outside hospital,precursor events,initial symptoms,cranial nerve involvement,cerebral pressure,protein concentration raise with cell count is normal,protein consentrations of CSF and electromyography(p>0.05).The effective rate of glucocorticoids combined with intravenous immunoglobulin in treatment of mild and severe patients is higher than that of glucocorticoids alone,but that has no statistical difference(p>0.05).Conclusions:Age > 50 years old,with autonomic nerve involvement,CSF Ig G elevation,QALB and plasma NLR were positively correlated with the degree of severity in GBS patient.Age > 50 years old and autonomic nerve involvement are independent risk factors for GBS.In this study,the cffective rate of glucocorticoids combined with intravenous immunoglobulin in treatment of mild and severe patients is higher than that of glucocorticoids alone,but that has no statistical difference.