Analyzing Infection Of Critical Ills In The Intensive Care Unit

Object To analyze pathogen distribution and antimicrobial resistance of critical ills in intensive care unit, in order to provide evidence for treatment of infection to critically ills in intersive care unite. Methord Analysising 1351 patients hospitalized in ICU From October 2007 to december 2008,there were 215 cases (including those within 48 hours discharged from ICU) who were cultured positive specimens and 558 pathogens were isolated in all. 126 cases were enrolled in ICU group according to《Diagnostic criteria of nosocomial infection》and 396 pathogenic bacterias were isolated, the others 89 cases belong to outside ICU group and 162 pathogenic bacterias isolated from those cases.We collected data on two groups patients .The following data were collected for each patient: basic data,sample source of pathogenic,pathogenic bacteria distribution. drug resistance rate of infection; outcome; the data were Analyzed and compared. Result Rate of nosocomial infection in Intensive Care Unit was 9.3%, sample source of sputum-positive ranked first, rate of respiratory tract positive isolated was significantly higher than that of outside ICU group(49.8% vs 16.7%, P<0.05) statistically pathogenic bacteria distribution isolated from patients, pathogenic gram-negative bacilli are dominated, pseudomonas aeruginosa ranked first in two groups, staphylococcus aureus were isolated most in gram-positive cocci bacterias. constituent ratio were close to each other in ICU outside group for enterococcus,staphylococcus aureus and coagulase negative staphylococcus. The prevalences of ESBLs in klebsiella pneumoniae and escherichia coli were 35.9%, 46.8% respectively.Rate of methicillin-resistant grape aureus (MRSA) isolated was 75%. Conclusions About source of Pathogen isolated, respiratory tract was dominated in ICU, source of infection in ICU group was significantly higher than that of outside ICU group(49.8% vs 16.7%), rate of bloodstream infection were close to each other in two groups. Pathogenic bacteria isolated were conditional pathogenic bacterias mostly, gram negative bacilli such as pseudomonas aeruginosa, baumanii , stenotrophomonas maltophilia and so on, gram positive coccus such as staphylococcus aureus , enterococcus feacium , enterococcus feacalis and so on . The rate of pathogenic bacterias antibiotic resistant were so high. rates of MRSA isolated were high in two groups. Therefore, medical staffs must use antibiotics rationally, strengthening the ward management, strictly implement aseptic technique and hand-washing system,preventing hospital infection,reducing the incidence of infection in ICU patients.