Distribution And Drug Resistance Of Common Pathogens In Intensive Care Unit (ICU)

Objective:To investigate the distribution and antibiotic resistance of clinical isolates from ICU inpatients in Binzhou People’s Hospital,so as to provide foundation for the clinical use of antibiotics.Methods:Various clinical samples were collected from ICU inpatients in Binzhou People’s Hospital from1Jan2011to31Dec2013, the pathogenic bacteria were identified by BD PhoenixTM-100automated microbiology system,the antimicrobial susceptibility was assessed by the Kirby-Bauer disc diffusion method,the data was analyzed by WHONET5.6Software.Results:A total of3449specimens were collected,1802non-repeated pathogenic strains were identified, the positive rate of separation was52.25%, with1399(77.6%) strains of gram-negative bacteria, which were dominated by Acinetobacter baumannii,33.74%(472/1399),Pseudomonas aeruginos23.02%(322/1399) and Klebsiella pneumonia17.16%(240/1399) while275isolates of Gram-positive bacteria accounted for15.26%(275/1802), mostly represented by Staphylococci accounted for59.27%(163/275) and Enter-ococc coccus accounted for23.27%(64/275),Fungi were128isolates (7.10%), which was dominated by53.13%(68/128) of Candida albicans. Most of the Gram-negative isolates showed high sensitivity to imipenem and meropenem, but high resistant to ticarcillin, ceftazidime, piperacillin. Gram-postive bacteria were high sensitive to vancomycin, teicoplanin, nitrofurantoin, linezolid, and chloramphenicol, but resistance to penicillin (100%). The positive rate of ESBLs producing strains of Acinetobacter Baumannii,Esch-erichia coli, Klebsiella pneumoniae were81.47%,74.19%and56.26%, respectively.Conclusions:Most of the isolates in the ICU of our hospital were Gram-negative bacteria and were resistant to most antibiotics. Surveillance of antibiotic susceptibility patterns is very important for providing basis for the rational clinical use of antimicrobial agents.