Study Of The Correlation Between Plasma Hcy, Hs-CRP, IL -6 And Vascular Cognitive Impairment No Dementia After Cerebral Infarction

Objective To investigate the correlation between the plasma homocysteine (Hcy), high sensitive C-reactive protein (hs-CRP),Interleukin-6 (IL-6) and Vascular Cognitive Impairment no Dementia (VCIND) after cerebral infarction.Methods Screening outpatient and inpatient of neurology department from First People's Hospital of Yinchuan City from March 2009 to March 2010, a total of 124 cases. Using the Mini-mental State Examination (MMSE) and the Chinese version of Montrea Cognitive Assessment (MoCA), they are divided into three groups: VCIND group (54cases), cerebral Infarction with normal cognition group (40cases) and control group(30cases). Compare these three groups's plasma of Hcy , hs-CRP and IL-6 .Results (1) Compared the cerebral Infarction with normal cognition group and control group,VCIND group plasma levels of Hcy, hs-CRP and IL-6 were significantly increased,These differences were statistically significant (P<0.05). Compared with the control group, cerebral Infarction with normal cognition group plasma levels of Hcy, hs-CRP were significantly increased,These differences were statistically significant (P<0.05), plasma levels of IL-6 were not differences ,These differences were not statistically significant (P>0.05).(2) Using Spearman correlation analysis,The plasma levels of Hcy was negative correlation with MoCA scores (P<0.05),The plasma levels of hs-CRP was negative correlation with MoCA scores (P<0.01),The plasma levels of IL-6 was no correlation with MoCA scores (P>0.05). The plasma levels of Hcy ,hs-CRP and IL -6 were no correlation each other (P>0.05). Using multiple linear regression analysis,βHcy=-0.42,tHcy=3.31,PHcy=0.002<0.01;βhs-CRP=-0.33,t hs-CRP=2.74,P hs-CRP=0.009<0.01;(3) Using ANOVA analysis, compared with the plasma levels of Hcy, hs-CRP, IL-6 of VCIND group's different infarct area,These differences were not statistically significant (P>0.05).Conclusion The plasma Hcy,hs-CRP levels may be the predictors of cognitive impairment after cerebral infarction, the concentrations of plasma Hcy, hs-CRP related with the cognitive impairment's degree of damage of VCIND after cerebral infarction.