Study For Dynamic Changes Of Serum Neuron Specific Enolase And Matrix Metalloproteinases In Patients After Severe Traumatic Brain Injury And The Correlative Clinical Indications

Objective:To investigate the changes in the serunm levels of neuron specific enolase and matrix metalloproteinases-2 and matrix metalloproteinases-9 and their clinical indications in the patients after severe traumatic brain injury.Method:A prospective control study was carried out.The serunm from 56 sTBI patients and 20 normal persons were collected to measure the levels of NSE,MMP-2 and MMP-9 by using ELISA and analyzed the change trend of them together with Glasgow Outcome Scale.Result:The serum levels of NSE,MMP-2 and MMP-9 were significantly higher in the brain trauma group than those in the control group(P<0.01). The serum levels of NSE peaked on 5th day,although dropping on the 7th day after brain trauma ,was significantly higher in the brain trauma group than that in the control group. The serum levels of MMP-2,MMP-9 peaked on 1st day and the second peak appeared on 5th day and than dropping on 7th day. The serum levels of NSE,MMP-2 and MMP-9 were significantly higher in the patients with poor prognoses group than those with good prognoses group(P<0.01).Conclusion:NSE,MMP-2 and MMP-9 of the serum were involved in the pathological process of acute brain injury, and might play an important role in secondary brain injury .Determination of their contents was of clinical importance for evaluation of the severity of injury and outcome prediction.