Background and objectiveWith the population aging, older adults with knee osteoarthritis incidence continued to rise.100 various types of arthritis, in which cartilage back into the main features of osteoarthritis of the hip is one of the most common type.38-60 years of age in our population,78.5% suffered from osteoarthritis. Beijing Hospital, Ministry of Health has led to the "China in the old state of osteoarthritis, " The results show that the country six regions (Northeast, North, East, South, Southwest, Northwest) people over the age of 40 patients with primary bone and joint diseases rate of 46.3%.Osteoarthritis of the knee more easily than the other diseases affecting elderly patients and walking, stair climbing and other lower limb function. Therefore, osteoarthritis is caused functional disability in the elderly population, resulting in economic losses and affecting social development, one of the major diseases. How to treat knee osteoarthritis, to improve the quality of life of patients, research is effective, safe, high titer of treatment intervention programs, population and health fields is an important issue facing with a wide range of urgent social needs.MethodsA randomized controlled trials of clinical research methods. Subjects based on research objectives and criteria (diagnostic criteria, inclusion criteria and exclusion criteria), will meet the standard Subjects were randomly assigned to oral administration of hot compress of Chinese medicine treatment and massage treatment group(treatment group), internal use of Voltaren group (control group), N=60 cases. Intervention schedule for 2weeks, every 1 weeks visiting a meeting, after a period of observation, and record the two groups before treatment one weeks later, after treatment of the scale results. Removed and falling standards:1, serious adverse events; 2, testing the process of the merger of serious diseases; 3, subjects with poor compliance, failure to carry out treatment in doctor's advice; four patients withdrew from the study on their own; five patients during follow-up lost to follow for various reasons. Comply with any one who removed from the study. The primary efficacy endpoint:patients, respectively, before treatment and after 2 weeks after the end of the use of internationally accepted course of treatment of knee osteoarthritis WOMAC scale. Rating Methods:100mm line at both ends, respectively, "pain" (0mm) recorded as 0 points and the "imaginary pain" (100mm) recorded as 100 points. Measured by the degree according to their feelings, in a straight line to mark the corresponding position, "painless" end-to-mark shall be judged by the distance between the (mm), arrive at the corresponding scores. Evaluation criteria:clinical recovery:the symptoms disappeared and normal functional activity, WOMAC osteoarthritis Total decrease≥95%; markedly:the symptoms disappeared, normal joint function, WOMAC osteoarthritis decreased≥66%; Effective:the pain disappeared, joint range of motion is normal, WOMAC osteoarthritis points decline≥33%; invalid:does not meet the standard of effectiveness or even increase, WOMAC osteoarthritis points decline≤33%or even increase.ResultsExternal application of treatment group,19 were males and 41 female, mean age 52.3 years, mean duration of 4.6 years, obesity in 8 cases,34 cases of right knee, left knee in 26 cases, before treatment the average WOMAC total score points 614.2±406.96 min, (pain items GPA 131.37±84.878 points, rigid entry GPA 61.90±53.225 points, functional items GPA 420.93±288.87 minutes); control group of 16 males and 44 females, average age 51.5 years, mean duration of 6.1 years, obesity in 9 cases,21 cases of right knee, left knee in 9 cases Before the treatment, the average points score 622.23±270.35 points (pain points in mean 129.33±68.94 points, rigid items GPA 24.73±18.319 points, functional items GPA 468.17±203.691 points). The sex ratio of three groups of patients, average age, weight, disease course, treatment points, compared with no significant difference (P> 0.05), after treatment, two groups of symptoms score Decreased significantly 1 weeks after the external application of treatment group symptom score decreased to 522.07±410.342 points (pain points in mean 103.90±74.054 points, rigid entry GPA 46.83±53.98 points, functional items GPA 371.33±304.973 points), control group symptom score decreased to 549.60+249.245 points (pain items average credit 117.70±62.389 points, rigid entry points average of 20.13±16.017 points, Function entry points 411.77±181.148 points on average),2 weeks after the external application of treatment group symptom score was reduced to 369.2 +358.36 points (pain points in mean 83.03±77.802 points, rigid entry GPA 30.73+42.9 points, functional items GPA 255.43±257.009 points), control group symptom score was reduced to 368.30+218.663 points (pain points in mean 72.97±52.906 points, rigid Item average credit 11.33±10.835 points, functional items GPA 284.00±161.925 points),Tow groups of symptoms one weeks after treatment total score was significant difference, the total effective of treatment group were 23.3%, the total effective of control group were 61.7%; two weeks after treatment the total effective of treatment group were 68.4%, the total effective of control group were75%. Tow groups of symptoms was no significant difference (P> 0.05).ConclusionHot compress of Chinese medicine treatment and massage treatment or internal use of voltaren treatment of osteoarthritis of the knee is an effective method. One weeks after treatment, the internal use of voltaren treatment was remarkably superior to the hot compress of Chinese medicine treatment. But two weeks after treatment, two method was no significant difference. As a result of TCM herbs has no harmful side effects. Worthy of clinical application. |