Evaluation Of Periodontal Treatment At TNF-α Levels In Chronic Periodontal Patients With Cerebral Thrombosis

Objective:By observing chronic periodontal with cerebral thrombosis (CPCT) patients before and after periodontal treatment of serum and gingival crevicular fluid levels of TNF-a changes, analysis of the relationship between CP and CT, and periodontal therapy in the prevention of recurrence of the role of CT, the risk factors of CT for the research and control are provided.Methods:64 chronic periodontal patients with cerebral thrombosis,the age between 50-69,were divided into two groups randomly.There are 32 patients in the CPCT treatment group receiving neurology specialist therapy and periodontal non-surgical treatment.The other thirty-two patients as the control one,only receive neurology specialist therapy.At the same time,forty chronic periodontal patients without cerebral thrombosis were collected as the CP treatment group who received periodontal non-surgical treatment.The periodontal indexes in 3 groups were detected at the baseline, one month and three month after the treatment.The levels of TNF-a(ELISA) of serum and gingival crevicular fluid(GCF) were measured in the patients for three times.The data was analyzed using SPSS 11.5 software carries on statistic analysis.Results:There is no significant difference in general condition clinical periodontal index (PLI, CI, BI, PD, AL) and gingival crevicular fluid levels of TNF-a between the three groups. CPCT treatment group and control group, serum levels of TNF-a was no significant difference. CPCT group of patients with serum TNF-a levels higher than the CP treatment group, the difference was statistically significant.After one month of therapy, compare with CPCT treatment group and control group:PLI, CI, BI, PD and GCF levels of TNF-a were significantly different; AL, serum TNF-a has decreased, but there was no significant statistical difference. Compare with CPCT treatment group and CP treatment group:BI, PD, AL, GCF TNF-a and serum TNF-a levels were significantly different; PLI, CI no significant difference.After three month of therapy, compare with CPCT treatment group and control group:All testing parameters are significantly higher, the difference was significant. Compare with CPCT treatment group and CP treatment group:BI, PD, AL, GCF TNF-a and serum TNF-a levels were significantly different; PLI, CI no significant difference.CPCT treatment group and the CP treatment group compared before and after treatment:AL has decreased but no significant difference; PLI, BI, AL, PD, GCF TNF-a and serum TNF-a more obvious differences. Treatment at 3 months compared with serum levels of TNF-a treatment decreased 1 month, but the difference was not statistically significant.After three month of therapy, CPCT treatment group than in the control group decreased recurrence rate of cerebral thrombosis, but the difference was not statistically significant. Before and after periodontal treatment of correlation analysis:Serum levels of TNF-a, respectively PD, BI, AL and GCF levels of NF-a showed a significant positive correlation.Conclusion:Under the identical general condition,there was a more serum levels of TNF-a in the patients with chronic periodontitis and cerebral thrombosis. Before and after periodontal treatment of correlation analysis: Serum levels of TNF-a, respectively PD, BI, AL and GCF levels of TNF-a showed a significant positive correlation. Periodontal therapy within 3 months after, CP patients effects were more stable than CPCT patients.Periodontal non-surgical treatment can decrease the levels of TNF-a and it may thus decrease their risk of cerebral thrombosis.