The Study On Distribution Regularity Of TCM Syndromes In Type 2 Diabetic Mellitus

The Study on Distribution Regularity of TCM Syndromes in Type 2 Diabetic MellitusObjectiveTo establish the database of "T2DM disease-syndrome diagnosis of TCM " based on T2DM date, theoretical research and TCM characteristics, under the rule of evidence-based medicine. By analysis of the distribution of T2DM disease-syndrome, the categorization rules of TCM disease name and syndrome were investigated so as to get prepared for T2DM disease-syndrome index.MethodsQualitative study method had been used for lterature research for the recent 20 years of T2DM, the theory study had been carried from both the modern and ancient data analysis. Records for the year 2003-2007 were collected, so as a database was established. Description of frequency was used to analyze the TCM disease name, syndrome name of the 1565 samples of T2DM and its complications. Chi-square-test was used to analyze the difference of the syndrome portions of the TCM diseases. Calculation and sorting were taken out by database.Results1 Literature research and Theoretical researchQualitative study of the literature showed that T2DM syndrome types up to more than 50 species. Syndrome differentiation methods were classified by different stages or other ways. Patterns of differentiation syndrome were classified by etiopathogenisis, by qi blood yin yang, by organs. Diseases name and etiopathogenisis are from practice. Different patterns had its characteristics.2 Data miningAmong the investigated patients,the maximum age is 92, youngest 14 year-old, while the average is 63.45±12.45, most of them are among 70-79 year-old,30.42% of the whole, while the 60-69 was 26.77% the second.The first five career were society service and inhabitant service 447 (28.6%), commerce service 177 (11.3%), professional technicist 71(4.5%), transport service worker 60 (3.8%), public health service workers 45(2.9%).The first six syndrome of the 1565 patients of T2DM and the complications were:qi and yin deficiency(48.95%),spleen and kidney deficiency (6.20%), live and kidney yin deficiency(4.35%), qi deficiency and blood stasis (4.22%), yin deficiency and dry heat (3.58%),damp-heat retention(3.45%), the first 5 syndrome pattern of 1017 T2DM patients were qi and yin deficiency (57.92%),spleen and kidney deficiency (5.21%),live and kidney yin deficiency(4.62%),yin deficiency and dry heat (4.62%),damp-heat retention(2.75%).Qi deficiency and blood stasis were the most common syndrome of Xiaoke and Tuoju.. Qi and yin deficiency, liver and kidney yin deficiency, spleen and kidney deficiency and yin deficiency dry heat were more usually seen in Xiaoke than in Tuoju. The distribution of T2DM and its complications had no relations with the period of in-patient treatment. The male patients had more damp-heat syndrome than in female patients, the female patients had more qi yin deficiency than in male patients.1103 of the whole 1565 patients (70.48%) of T2DM and its complications were under differential syndromes of qi-xue-jin-ye which was the most commonly used syndrome differentiation method. The etiopathogenisis syndrome differentiation was damp-heat retention, Qi-blood fluid syndrome differentiation was qi-yin deficiency, qi deficiency and blood stasis,yin deficiency and dry heat, yin deficiency, yang deficiency, qi stasis and obstruction by phlegm, The organ syndrome differentiation were spleen and kidney deficiency and liver and kidney yin deficiencyConclusions:Syndrome types in T2DM showed diversification and complication. Syndromes differentiation for different stage of T2DM had become a trend, of which yin-yang qi-blood fluid syndrome differentiation was the mainly used one. The distribution and evolution of T2DM syndromes had some regularity. There were significance between the distribution of disease-name, gender, and T2DM and complications. DM basic pathological mechanism of "vigorous fire hurt qi" theory." heat hurt qi-yin" and pathological hypothesis of "micro-Zhengjia" had probably been the cause of the distribution of T2DM and its complications.