Clinical Investigation Of Pre-warning In Pregressive Stroke

Objectives:To evaluate the significance of pre-warning of Lysophosphatidic acid on the progressive stroke; Provide a new pre-warning methods for progressive stroke; LPA become a routine examination in patients ischemic stroke.Object and Method:Object:Select hospitalized patients with stroke in January 2007-in March 2008 at Department of Neurology Affiliated Hospital Chifeng Institute. Group progressive stroke and group non-progressive stroke as the growth of the disease.Methods:First, score all patients at admission,24 hours after onset,48 hours,72 hours with the National Institutes of Health Stroke Scale(NIHSS),at the same time all patients underwent head CT to determine infarction lesion site,size.;asked about the gender, age, smoking and drinking history; previous coronary heart disease, diabetes, history of hypertension to patients and their families; Record blood pressure and body temperature at the time of admission. All patients were at admission,24 hours after onset,48 hours,72 hours LPA was extracted. Lysophosphatidic acid reagent kits purchased from Beijing to TaiFuShi Technology Development Corporation, and the remaining for domestic reagents, reagents configured for dual-distilled water, operation accordancing to instructions strictly In addition, determination blood glucose, blood lipids (including total cholesterol, triglycerides, low concentrations of lipoprotein, high concentrations of lipoprotein) fibrinogen, platelet. Finally using statistical software SPSS13.0 deal, when compared to the two groups,using X2 test for countdata and X±S for measurement data. Determine the relation of Lysophosphatidic acid in the progressive stroke.The result:Compare of clinical and imaging examination in two groups. Between the two groups of age, gender, smoking, alcohol consumption, was not significant (P> 0.05) were compared in patients with laboratory indicators,between the two groups of platelet and LAP has significant difference.LPA levels and the incidence of PS incidence was significantly increase With the high of plasma LPA levels trend of admission when LPA is 7.0 ummol/L or more, all of the patient is progress.Plasma LPA levels (umol/L)in different time were higher in progressive and complete stroke at 24 hours after onset of were higher, there is significant difference in the progressive syroke and complete stroke after onset of plasma levels of LPA levere at different time points (P<0.05, P<0.01, P<0.05).The relationship between plasma LPA level and the infarct site. Plasma LPA levels is high in the cortex of patients than the subcortical group in progressive stroke group, but the difference was not significant.Severity of disease associated with plasma LPA. Severity group LPA higher than that of light, medium group (P<0.05); medium group higher than that in mild group (P <0.05).Conclusion:This research shows that patients with cerebral infarction within 24h plasm lysophospholipids acid level>7.0 umol/L occur progressive, the value is early warning, deserves further study.The level of lysophospholipids acid within 24h,24h,48h,72h, is higher in progressive stroke group compared with the non-progressive group, from onset to reach peak incidence 48h,, when plasma LPA were> 5.0 umol/L or more than normal in 48h, progressive is occur. At this point LPA is warning factor.The comparison of LPA level with infarct size. infarct seriousness in PS,found LPA lever is higher than other groups.Search significance:Provide a theoretical basis for study pre-warning progressive stroke.; Provide medical examination for the progressive stroke patients.; Provide theoretical support.for subsequent intervention study; LPA is application to basic-level hospitals, easy to accept.