Relationship Between Plasma Lysophosphatidic Acid Levels And Prognosis In Ischemic Stroke

Objective Plasma lysophosphatidic acid(LPA) levels were determined to explore the relationship between plasma LPA levels and the infarction size,neurologic impairment degree(NIHSS score), prognosis(BI score) in patients with acute cerebral infarction.Methods Plasma LPA levels were determined in patients with acute cerebral infarction(ACI group) in the time of 24 h,the third day,the seventh day, the fourteenth day and the twenty-one day after onset of stroke,All patients'neurologic impairment degrees were evaluated by the National Institutes of Health Stroke Scale(NIHSS) at corresponding time points,and prognosis was evaluated by Barthel Index(BI) at the ninety day.Plasma LPA levels were also determined in forty patients with transient ischemic attack (TIA group) and sixty-two age-and sex-matched healthy controls(control group).Results: 1 Plasma LPA levels in ACI group and TIA group were 5.10±1.44umol/L and 5.04±1.33umol/L respectively in the time of 24h after onset of stroke, increased markedly compared to that of control group which was 2.32±0.64umol/L (P <0.001).With time elapsing,it decreased in ACI group,and restored to normal level at the fourteenth day (compared to the control group,P=0.101). 2 There was significant difference for plasma LPA levels among patients with larger,middle and smaller size of infarction lesion in the time of 24h after onset of stroke in ACI group(F=15.21,P<0.001), 6.21±1.25umol/L,5.01±1.26umol/L and 4.01±0.87umol/L respectively. 3 In ACI group,there was significant linear positive correlation between plasma LPA level and NIHSS score in the time of 24h,at the third day,the seventh day,coefficient correlation(r) was 0.706(P<0.001), 0.433(P=0.002) and 0.338(P=0.016) respectively;There was no correlation between plasma LPA level and NIHSS score at the fourteenth day,the twenty-one day. There was significant linear negative correlation between BI score and plasma LPA level in the time of 24h (r=-0.607,P<0.001); There was no correlation between BI score and plasma LPA level at the third day,the seventh day, the fourteenth day,the twenty-one day. Conclusion Plasma LPA levels increase markedly in patients with acute cerebral infarction,being a reliable biomarker for diagnosising and predicting prognosis.