The Preparation Of Drug-Loaded Pan Fibers And Evaluation Sustained Release Performance

It is based on interdisciplinary approaches, which combine polymer science, pharmaceutics, molecular biology and advanced technologies that new DDS (Drug Delivery System) continuously come into pharmaceutical markets. Not only biotextiles and textiles technologies have some concrete advantages over other materials and the corresponding technologies in pharmaceutical field, but also they can offer new methods and approaches for the preparation of novel DDS. DDS from biotextiles can make patients live easy, improve efficacy and compliance, which are the forever goals of pharmaceutics. Development of novel DDS from biotextiles represents one of the future important orientations for both pharmaceutics and technical textile fields. With polyacrylonitrile (PAN) as matrix and N,N-Dimethylacetamide(DMAc) as the solvent, three different kinds of drug loaded fibers were prepared with wet-spinning process, electrospinning process and modifying electrospinning PAN nanofibers respectively. The properties and the in vitro drug release property of all the drug loaded fibers were investigated.The drug loaded fibers prepared with wet-spinning method were theoretically strong enough for textile processing, which indicated that the fibers developed with wet-spinning method in this research can be manufactured into drug loaded textiles. And the application of HPMC (hydroxypropyl methylcellulose) can modify the vitro drug release profile of the drug loaded fibers. The actual content of drug in the drug loaded fibers prepared with wet-spinning process was lower than the loading content of it because of the diffusion of drug from fiber into spinning bath.UV was used to determine the drug loading of the fibers. Three kinds of drug loaded fibers were identified by IR, SEM and DSC test. The results showed that tamoxifen can be bonded with PAN through hydrogen bond in wet-spinning and electrospinning drug loaded fibers, most of the loaded TAM were converted into the amorphous state. And sodium salicylate can be bonded with PAN through electrovalent bond in the drug loaded ion-exchange nanofibers.In vitro release properties and release mechanism were studied by dissolution apparatus and UV. The curve of the percentage of the cumulative release versus time was made. The results showed that the initial burst effects were manifest in all the drug loaded fibers. The drug loaded fibers prepared with wet-spinning process could release all the tamoxifen they can release during the 15 days dissolution periods, and the application of HPMC in the drug loaded fibers can modify the vitro drug release profile of it. The ultrafine drug loaded fibers prepared with eletrospinning and ion-exchange fibers were able to control the drug release all the drug they can release during the 12 hours dissolution periods.