Electrospun P(LLA-co-CL) Membrane For Controlled Drug Release

This thesis includes the study on drug-loaded spinning biological materials.The textile fibers with L-lactide-caprolactone copolymer(P(LLA-co-CL)),poly ethylene oxide(PEG)and PCL are prepared using uniaxial and coaxial spinning techniques, resuting in the fibers with different structures and compositions.Drud releasing behaviors from the fibers are compared.A series of different compositions of the P(LLA-co-CL)were prepared.By electro-spinning experiments,LA / CL = 70/30(by mol)of P(LLA-co-CL) copolymer was ultimately chosen as the substrate.Electro-spinning with PEG and PCL,the drug-loaded textile fibers were prepared in different structures and compositions.Two drugs with different hydrophilicity(indomethacin and chloramphenicol)were embedded in the fibers.SEM results showed that the electrospun fibers were in good shape,and no drug particles gathered on the fiber surface.The releasing behaviors of the two model drugs from the drug-loaded fibers were investigated.The results showed that the releasing rate of the the drugs from the core-shell fiber was significantly retarded in comparison with that from the blend fibers,althougth both of the releasing profile following the mechanism of the Fickan diffusion.The research of this thesis reveals that the releasing of drugs can be easily regulated by changing the structure and composition of the fibers to meet different application requirements.