Glucocorticoid Treatment Of Allergic Rhinitis Clinical Analysis

Objective:1. Through the nasal mucosa of allergic rhinitis in patients with glucocorticoid receptor to carry out analysis to understand the distribution of its expression.2. To further explore the expression of glucocorticoid receptor with the distribution of glucocorticoid resistance. At the same time guiding the rational use of clinical glucocorticoid, and optimize treatment strategies for allergic rhinitis.Materials and Methods:Collected in January 2008 during the month -12 Second Affiliated Hospital of Dalian Medical University otolaryngology out-patient clinics and 45 cases of hospitalized patients, as one of 30 cases diagnosed in patients with allergic rhinitis, according to glucocorticoid therapy and outpatient follow-up divided into hormone-sensitive and steroid-resistant groups, each of the 15 cases of patients, choice of inferior turbinate mucosa as a front-end study. Another 15 cases from nasal septum deviation surgery patients (excluding allergic rhinitis and a history of allergic diseases), with the parts of nasal mucosa as the control group. Through HE staining and immunohistochemical SP method, detection of nasal mucosa glucocorticoid receptor expression and their geographical distribution. Finally, exp- erimental data were statistically analyzed. In all experimental cases did not receive 2 weeks of glucocorticoid, anti-histamine drug, in part or (and) systemic medication.Results:Glucocorticoid receptor in hormone-sensitive group, steroid-resistant group and the normal control group, in varying degrees of positive expression. Reflected mainly in the cytoplasm, nucleus appear light yellow to brown granules stained positive. Mainly expressed in epithelial cells, submucosal gland epithelial cells, vascular endothelial cells and inf- lammatory cells. Of hormone-sensitive group, the resistance group and the control group of glucocorticoid receptor positive cells expression data were analyzed statistically. SUK tested by hormone-sensitive group and the resistance group and the control group with the resistance group, there was a significant difference (P <0.05), there is statistical significance. And sensitive group and the control group no significant differences (P> 0.05).Conclusion:1. Patients with allergic rhinitis nasal mucosa glucocorticoid receptor expression levels, are the impact of glucocorticoid treatment effect of key factors. Glucocorticoid receptor expression is higher on the treatment of glucocorticoid-sensitive, and glucocorticoid receptor expression in lower glucocorticoid treatment is not sensitive.2. Glucocorticoid receptor structure abnormalities, reduction in the number or functional defects, and glucocorticoid resistance may exist related to each other.3. By detecting patients with allergic rhinitis nasal mucosa gluco- corticoid receptor expression, can guide the clinical rational use of gluco- corticoids, while optimizing the treatment of allergic rhinitis strategy.