A Study For The Expression Of Claudin-5 And Claudin-10 In Colorectal Carcinoma

ObjectiveTo investigate the expressions of Claudin-5 and Claudin-10 in colorectal carcinoma(CRC) and its significance.Methodes Pathological verified,50 colorectal tissue(CRT), 25 colorectal adenoma(CRA),25 non lymph node metastasis CRC(non-LNM CRC) and 25 lymph node metastasis CRC(LNM CRC) were detected for the expression of Claudin-5 and Claudin-10 by immuno-histochemical SP(Streptavidin Perdcidase) method.Results1.The positive expression rates of Claudin-5 were 82%,76%,68% in CRT,CRA,CRC,respectively.The positive expression rate of Claudin-5 in different groups was not significantly different(x~2=2.638 p＞0.05).Claudin-5 expression was correlated with LNM(p＜0.05),but was not correlated with sex,age,location,differentiation,tumor diameter and serous membrane invasion(p＞0.05).2.The positive expression rates of Claudin-10 were 54%,56%,72% in CRT,CRA,CRC,respectively.The positive expression rate of Claudin-10 in different groups was not significantly different(x~2=3.839 p＞0.05).Claudin-10 expression was correlated with tumor diameter, serous membrane invasion and LNM(p＜0.05),but was not correlated with sex,age,location and differentiation(p＞0.05).3.There was no significant correlation between Claudin-5 expression and Claudin-10 expression in CRC.(r=0.050,p=0.732)Conclucions1.Claudin-5 and Claudin-10 are expressed in CRT,CRA,CRC. They are not involved in CRC occurrence.2.Claudin-5 and Claudin-10 abnormally expressions are significantly associated with the incidence of LNM.Meanwhile, Claudin-10 expression is correlated with tumor diameter and serous membrane invasion3.There was no significant correlation between Claudin-5 expression and Claudin-10 expression in CRC.