Effect Of Ulinastatin On Renal Function In Live Donor Renal Transplantation

Objective:Live donor organ transplantation,especially live donor renal transplantation has become an effective way to relieve the shortage of transplant organs and improve the quality of graft.But now the study on the donors' organ protection during the perioperative period was rare. The aim of this srudy is to investigate whether the use of ulinastatn on donor can protect the kidneys and improve the quality of grafts.Methods:Forty pairs of patients were randomly assigned to four groups according to the use of ulinastatin:ulinastatin donors group(Ud) and relevant recipient group(Ur),control donors group(Cd) and relevant recipient group(Cr),each group has 20 patients.The patients of Ud group were given 5000 unit/kg ulinastatin by intravenous pump since anesthesia,and the patients in other group were not given ulinastatin. Blood sample of donors were collected to detect serum Cys-c andαl-MG level at time before anesthesia(T1),block the vessel of kidney(T2) and at the end of the operation(T3).Blood sample of recipient were taken at time before anesthesia(T1~/),the end of the operation(T2~/) and 24h after operation(T3~/).The serum Cys-c andαl-MG level were detected with the method of ELISA(enzyme-linked immunoabsorption assay).And the urinary output in 24h after operation were also recorded.Results:1.There is no significant difference between two domor groups(recipient groups) in age,sex,weight,height,hemodynamics,the duration of operation,and the total volume of fluid infused(P＞0.05);The urinary output of Ud and Cd groups were little more than Ur and Cr groups,but there is no significant difference(P＞0.05)2.The serum Cys-c level of group Ud were significantly lower than group Cd at T2 and T3(P＜0.05),but at T1,there is no significant difference.There were no significantly difference beween the recipient groups(P＞0.05)3.The change of serumαl-MG level was similar with serum Cys-c.Conclusions:1.The use of ulinastatin on donors can significantly reduce the rise of serum Cys-c and serumαl-MG during the perioperative period.2.The dose and dosage regimen of ulinastatin in this study don't have significant improvement on the grafts.