Analysis Of The Safety Of Elderly Living Related Kidney Donors

ObjectiveTo explore the safety, feasibility and transplantation effect of the elderly donors in theliving related donor kidney transplantation．MethodsAccording to donor age were divided into two groups,Forty-five elderly donors(51—78years， study group)who underwent nephrectomy for living related donor kidneytransplantation from April1993to December2007were retrospectively investigated. Thefollow-up time ranged from12to180months, average49months. Clinical data includingserum creatinine(SCr)，glomerular filtration rate(GFR)in pre-and post-operation wereanalyzed and compared with the control group(62cases，the donors age were younger than50years);The recipients after renal function recovery, complications and close, long-termgraft function, man/kidney survival rate.ResultsThe operations of all living donors were successful． The SCr and GFR inpre-operationwere(82.16±10.86)tumol/L,(85.82±6.26)ml/min(studygroup)and(78.66±10.41)#mol/L,(88.74±9.44)ml/min(control group)respectively． There were no significantdifferences in SCr and GFR between the groups at different time points(P>0.05); Twogroups of preoperative glomerular filtration rate were(85.82±6.26)ml/min (88.74±9.44)ml/and min, after January and December were (49.76±3.57)ml/min60.32±4.42ml/,min (Study Group) and(51.36±5.39)ml/min (62.10±6.31)ml/, min (control group), thedifferences between groups were not statistically significant (P>0.05). The donoroperation complications included3cases of injury of pleura (elderly group of2cases,1cases of young group); the lower abdomen incision pain, numbness in13cases (4cases ofsenile group, young group9cases); the elderly group had incision fat liquefaction in1cases. Follow up showed elderly kidney donor renal function remained normal, no cases ofdeath due to abnormal renal function. Two groups of subjects in the age, sex ratio, preoperative dialysis time, typing, renal ischemia time, anti rejection scheme applicationshows a good balance,1weeks after operation, in January,1years,3years of serumcreatinine level and1,3,5,8year survival rate of human/kidney group differences werenot statistically significant (P>0.05).ConclusionDonor age>50years of living related donor kidney transplantation, donor safety andtransplantation effect were satisfactory. The age of non living donor kidney absolutecontraindications, preoperative evaluation and postoperative comprehensive carefuloperation can ensure the elderly postoperative donor safety and transplantation effect.