Clinical Intervention Research Of Tongmai Granules To Atherosclerosis Patients Of Interleukin-6 (IL-6)

Objective:To observe and analyze Tongmai Granules of atherosclerosis(AS) patients with serum interleukin-6(IL-6) the role of the clinical intervention,and Tongmai Granules of atherosclerosis in patients with clinical symptoms to improve the situation.Methods:According to the standard collection of cases from January 2008 to December 2008 in our department for treatment of 100 cases of out-patient clinics and patients,according to the order in which they were randomly divided into treatment Tongmai Granules group (observation group) and simvastatin(control group) to observe the group was given Tongmai Granules treatment,the control group taking simvastatin treatment,and in accordance with the standards of TCM Syndrome Types of Qi is divided into,two types of blood stasis.The two groups were 30 days for observation of a drug treatment,respectively,1 day before treatment,the treatment of one end of the first day of the evaluation of clinical symptoms, serum IL-6(IL-6) level of determination,and stop 15 days after the re-determination of IL-6 (IL-6) level,all the data using statistical software SPSS 13.0 for statistical analysis.Results:1.by t test,pre-treatment comparison between the two groups P＞0.05,no significant difference,comparable;treatment group before and after 30 days compared with serum IL-6 were significantly lower(P＜0.01);the difference between the two groups(P＜0.05),with statistical significance,the observation group a little better than the control group.2.15 days after the review of drug serum levels of IL-6 in the control group a higher proportion of elevated(54.35%),the lower the observation group(9.80%),observation of serum IL-6 level of a higher proportion(58.81%),indicating that Tongmai Granules at lower levels of IL-6 the role of a more durable and maintain a long period of time.3.group of Chinese medicine treatment of symptoms 30 days after total effective rate was 83.33 percent,43.33 percent for the control group,by rank sum test comparing the difference between the two groups significantly(P＜0.01),traditional Chinese medicine in improving symptoms,significantly better than the control group.4.according to rank sum test,Chinese medicine mainly as individual symptoms and tongue,the pulse of the score,the two groups before treatment was no significant difference(P＞0.05);but after 30 days treatment group compared with the pre-treatment difference was significant(P＜0.01),the difference between the two groups also very significant(P＜0.01);the control group before treatment,treatment for 30 days,respectively, no significant difference(P＞0.05),traditional Chinese medicine significantly better than the control group in individual symptoms and tongue,the pulse of the score,.Conclusion:1.Tongmai Granules significantly improved atherosclerosis(AS) in patients with clinical symptoms.2.Tongmai Granules effective to reduce atherosclerosis in patients with serum IL-6(IL-6) level,the role of time is long,low relapse rate after drug withdrawal.3.Tongmai Granules Chinese medicine in the treatment of the doses had no significant side effects and adverse reactions.4.Tongmai Granules of atherosclerosis in patients with inflammatory mechanism worthy of further study in future.