Bushen Huoxue Treatment Of Kidney Deficiency And Blood Stasis Perimenopausal Dysfunctional Uterine Bleeding Of Clinical Research

Objective:To observe the effect of the treatment of kidney deficiency and blood stasis perimenopausal dysfunctional uterine bleeding of clinical effectiveness,safety,explore treatment Bushen Huoxue mechanism of this disease,the clinical application of Chinese medicine to provide a scientific basis.Methods:from January 2007 to June 2008 in Hubei Province during the Chinese medicine hospital out-patient gynecological clinic, diagnosed with kidney deficiency and blood stasis perimenopausal patients with dysfunctional uterine bleeding,for a total of 60 cases were randomly divided into two groups:treatment group 30 cases,30 cases of the control group.Since the treatment group given prescriptions to be phased treatment,bleeding period:Health Puhuang speculation the 10g,Cuscuta 20g,Psoraleae 15g,virgin carbon 20g,donkey-hide gelatin 10g,dry grass-lian 24g,Agrimoniae 20g,Pseudostellaria 15g,Baicalin 8g.Bleeding period:Cuscuta 20g,Psoraleae 15g,Pseudostellaria 15g,Dendrobium 15g,amethyst 20g,Salvia 20g,Cyperus 12g,zeeland 10g,bark 15g,1 day,thick fried 200ml,sooner or later,the second serve points.Control group:Fu Kang Pian,each oral 5mg,every 8 hours 1 times,bleeding stopped,the decrease on the 3rd of each 1/3 volume,up to a daily maintenance dose 5mg,continued to use only after blood withdrawal on the 20th.Withdrawal bleeding waiting for the first five days of the beginning of the next cycle,each oral 2.5mg,every 12 hours 1 times maintain a total of 22 days.The above-mentioned three methods for the treatment of bleeding as a treatment cycle.Observed after treatment of clinical efficacy in patients with recent bleeding time,traditional Chinese medicine symptom efficacy,changes in hemoglobin content,B-under the endometrial thickness as well as long-term relapse rate of patients with blood,urine,liver and kidney function tests,such as security.Data obtained from the measurement data using t test,χ~2test the use of count data,the use of Ridit level data analysis.Results:①The two groups of patients three months after stopping the integrated effects:treatment group 93.33%efficient,for the control group was 83.33%efficient,by the statistical processing, were significantly different(P＜0.05),that the treatment group Integrated effective than the control group;②recent bleeding time: two recent hemostasis time were significantly different(P＜0.05), show that the control group,bleeding time in the near future better than the treatment group;③perimenopausal symptoms effects of Chinese medicine:After treatment,the treatment group and control group effects of traditional Chinese medicine symptoms were significantly different(P＜0.05),stopping three months after the treatment group compared with the control group were very significantly different(P＜0.01),show that the treatment group in improving the Wai aspects of traditional Chinese medicine symptoms of menopause than the control group;④before and after treatment hemoglobin(Hb) content in comparison:the treatment group before and after treatment hemoglobin values were significantly different(P＜0.05),the control group before and after treatment hemoglobin values were significantly different(P＜0.05),after treatment hemoglobin values between the two groups were significantly different(P＜0.05),that the treatment group and control group can raise the hemoglobin concentration,but the treatment group than the control group;⑤womb before and after treatment Comparison of film thickness change:pre-treatment of patients with endometrial thickness of the two groups showed no significant difference(P＞0.05),comparable;the treatment group after treatment compared with before treatment were significantly different(P＜0.05);the control group compared with before treatment were significantly different(P＜0.05);between the two groups after treatment compared with no significant difference(P＞0.05),two groups of drugs that patients can reduce endometrial thickness and no significant difference;⑥drug relapse after six months compared to the situation in follow-up:treatment group 17.86%recurrence rate in the control group 44.00%recurrence rate,the two groups of patients with relapse after treatment compared to the situation in six months the difference was statistically significant(P＜0.05).rhat long-term effect of the treatment group than the control group.⑦safety monitoring and adverse reactions:two groups of patients before and after treatment of blood,urine,liver and kidney function and ECG abnormalities are not obvious.The control group only in four cases during the medication in patients with mild dizziness fatigue,two cases of nausea,1 patient had drowsiness,but may insist on continued use.Conclusion:Bushen Huoxue medicine in the treatment of kidney deficiency and blood stasis perimenopausal dysfunctional uterine bleeding have a good clinical efficacy,low recurrence rate,and no obvious side effects and adverse reactions,particularly in the perimenopausal symptoms of clinical aspects of has great advantages, it is widely used clinical.Bleeding time in the near future but not as good as Western medicine,so the need for further study and improve the future.