A Research On Plasma Adiponectin Concentrations,Ankle Brachial Index,and Pulse Wave Velocity Correlated With Coronary Artery Disease

Objective Adiponectin(APN) is a kind of lipoaspiration-derived collagenase-like plasma protein,which could be anti-antiatherogenic,antiphlogistic and improve the sensibility of insulin.To investigate the variation of plasma adiponectin(APN),the ankle brachial index(ABI),and the pulse wave velocity(PWV) in patients with the coronary heart disease(CHD) and explore the correlation between them,especially the meaning and of those to the diagnosis of CHD.Methods A total of 98 subjects who attended the cardiovascular department of the affiliated hospital of Qingdao university medical college from Aug 2007 to Jun 2008 were enrolled.The subjects were divided into normal control group(n=23),the ACS group(n=43) and the SAP group(n=22) by angiography.Serum concentrations 'of adiponctin were evaluated by ELISA system,the the ABI and the PWV were tested by the non-invasive vascular screening device.Grouped the patients by type of CHD, the result of coronary arteriongraphy PWV and ABI.Compared the APN,PWV,ABI of each group.Results The APN of ACS group was lower than that of normal group and SAP group.while the APN of SAP group was lower than that of normal group.The PWV of CHD group was higher than that of normal group,the ACS group was higher than that of SAP group and normal group,SAP group was higher than normal group,the difference was of statistical significance.The ABI of ACS group was lower than that of normal group and SAP group,the difference of SAP group and normal group was of no statistical significance.The APN of CHD group was lower than that of normal group,the trifurcate vessel diseased group was lower than normal group,single vessel diseased group and double vessel diseased group.the double vessel diseased group was lower than that of single vessel diseased group and the normal group.There was statistical significance in every two group but the single vessel diseased group and the normal group.The ABI of the trifurcate vessel diseased group was lower than normal group,single vessel diseased group,and double vessel diseased group.the double vessel diseased group was lower than that of single vessel diseased group and the normal group.there was no statistical significance between single vessel diseased group and normal group.Tested the PWV of patients and grouped them by the PWV,there was 27 patients in PWV＜1400cm/s group,32 patients in 1400cm/s～1800cm/s group,29 patients in PWV＞1800cm/s group,compared the APN and ABI of each group,there was statistical significance between every two groups.Grouped patients by ABI,compared the APN and PWV of every two groups,the APN of ABI＜0.9 group was lower than that of ABI＞0.9 group and the PWV higher was higher.Conclusion The plasma APN levels are significantly lower in patients with CHD,the PWV is higher,the ABI is lower.The PWV will be higher and the ABI will be lower,while the APN of CHD patients decrease.The levels of plasma APN has close relationship with the severity of coronary artery stenosis,the stability of atherosclerotic lesion.The APN,ABI and PWV might be new risk factors of CHD, and provide a new and convenient way for us to evaluate and diagnose the severity of coronary artery diseaseDynamic monitoring of APN,PWV and ABI maybe provide a new way of CHD early diagnosis,pathogenetic condition monitoring and prognosis judgement for the clinician.