The Clinical Research On The Changes In Immunization Indicators Of The COPD Patients In Acute Phase And Remission

Objective:To observe the index of T-lymphocyte subsets,Immunoglobulins and Complements in COPD Patients,Comprehensive grasp of the changes in immunologic function of COPD Patients。Methods:Strict according to the standards,select COPD Patients as the observation group,healthy persons as the control group,detect the levels of CD₃⁺,CD₄⁺,CD₄⁺/CD₈⁺,IgG,IgA,IgM,C3,C4 and CH50 in the COPD patients with the acute phase and remission and the healthy persons.Set up database,use reasonable statistics,analyse the changes of the COPD patients' immune function。Results:1.Two groups of patients haven't Significant difference in age and sex(P＞0.05),so They have comparability;2.The acute phase compared with the control group,the levels of CD₃⁺,CD₄⁺,IgG and C3 declined,and have Significant difference(P＜0.05) the levels of CD₄⁺/CD₈⁺,IgA declined,the levels of IgM,C4,CH50 rise up,but haven't Significant difference(P＞0.05);3.The Remission compared with the control group,the levels of CD₃⁺,CD₄⁺,CD₄⁺/CD₈⁺,IgG,IgA declined,the levels of IgM,C3,C4,CH50 rise up,but haven't Significant difference(P＞0.05);4.The acute phase compared with the Remission,the level of C3 declined,and have Significant difference(P＜0.05);the levels of CD₃⁺,CD₄⁺,CD₈⁺,IgG,IgM,C4,CH50.the levels of CD₄⁺/CD₈⁺,IgA rise up.but haven't Significant difference(P＞0.05); 5.In acute phase,the type Feipishenxu tanreyuzu patients compared with The type Feipishenxu tanyuneizu patients,the levels of C4,CH50 declined,and have Significant difference(P<0.05);the type Feipishenxu tanreyuzu patients compared with The type Feipishenxu tanzhuoneizu patients,the level of CH50 declined,and have Significant difference (P<0.05)。6.In remission,the type Feipishenxu tanreyuzu patients compared with The type Feipishenxu tanyuneizu patients,the levels of C3,CH50 declined, and have Significant difference(P<0.05);the type Feipishenxu tanreyuzu patients compared with The type Feipishenxu tanzhuoneizu patients,the level of CH50 declined,and have Significant difference(P<0.05)。7.In type Feipishenxu tanzhuoneizu patients,the immunization indicators haven't Significant difference phase;in type Feipishenxu tanyuneizu patients,the level of CH50 declined in acute phase,and have Significant difference(P<0.05);in the type Feipishenxu tanreyuzu patients,the levels of CD₈⁺,C3,C4 declined in acute phase,and have Significant difference(P<0.05)。Conclusion:The immune function of COPD patients decline in varying degrees, and significantly in acute phase。The immunization indicators of type Feipishenxu tanreyuzu patients' are Lower than the Other type,and the Complements is Particularly。When the COPD patients are taking general treatment,we Should improve their immune function positively。The TCM is Useful for Treatment of patients with COPD,and improve immune function may be one of the Breakthrough point。...