| Asthma, a common medical condition, is on the rise. Globally, there are approximately 150 million asthmatic patients. Amongst which 180 thousand die from the illness each year. Based on these figures, it is clear that asthma is a chronic medical condition that threatens the well-being of human health. In the year 2000, asthmatic analytical research report had recorded that 1.97% of Singaporean children were asthmatic. Therefore, the prevention of asthma has become a global issue. World Health Organization (WHO) has also classified the fight against asthma on a global scale.Asthma can be categorised into acute attack, chronic duration and the remission phase. It is crucial for asthmatic children to engage proactively in the various phases of the treatment. The treatment of asthma during the remission phase in order to prevent and reduce the attacks is deemed very important. The Chinese medicine is superior in regulating the overall health of a person. Depending on the principle of differentiation and treatment,it is very effective in the various stages of treatment as well as the prevention of asthma. Based on the existing knowledge on the remission phase of asthmatic treatment, this thesis analysed the effects of consuming the medicine at different timings of the day. Through close observation of 68 cases of child asthmatic patients with weak kidney function, detailed analysis on the effects of consuming "Shen Ge Xi Xin San" at different timings of the day was performed. The results that the medicine had on the patients were tabulated and analysed based on short-term and long-term recoveries. A point system was applied to classify and grade the effects of the administration of the medicine on 2 different sets of timing - Morning only ; Both morning and evening. During the study, the safety aspects of using the medicine was also closely followed and recorded. From the study, medical effects and the safety of the medicine was observed, analysed and recorded. In addition, other beneficial effects of the medicine was also noted.Objective: To investigate the time administration effect of "Shen Ge Xi Xin San" on the remission phase of asthma affecting children with weak kidney function based on the "Zi Wu Liu Zhu" logic.Method: The experimental subjects to this research were 68 asthmatic children with weak kidney function. They were the patients at the Singapore Chung Hwa Medical Institution and Natural TCM Clinic. Based on the concept of a blocked and randomized statistical model with a ratio of 1:1, the subjects were divided into 2 groups, namely the experimental group and the control group. Each group of patients was administered with the "Shen Ge Xi Xin San" with 1 to 3 courses at 12 weeks duration for each course. The experimental group was administered with the medicine each morning whereas the control group was administered both mornings and evenings. The results were obtained by applying a point system. The findings were concluded by analysing the points using specific statistical models, thus commenting on the effect of the different methods of administering the medicine as well as the safety aspects.Result: Based on the concept of a randomized statistical model with a ratio of 1:1, 68 sick children were administered with "Shen Ge Xi Xin San". The experimental group was administered with the medicine each morning whereas the control group was administered both mornings and evenings. Results of the 2 groups were analysed. The analysis between the 2 groups was plausible because both groups observed similar characteristics in age, sex,condition and course of the illness.Post-treatment results displayed significant improvements for most of the symptoms of the illness. However for both groups, no significant improvements were observed for flu and allergic symptoms. Post-treatment analysis displayed better results for the control group than the experimental group in the tolerance to cold. For the rest of the symptoms, both groups displayed similar results. The experimental group concluded with 2 significant success cases (5.9%), 21 success cases (61.76%) and 11 status-quo cases (32.35%) resulting an overall success rate of 67.64%. The control group concluded with 2 significant success cases (5.9%), 22 success cases (64.10%) and 10 status-quo cases (29.41%) resulting an overall success rate of 90%. There were no significant differences between the results of both groups and it was possible to achieve a success rate of 70.59%. In addition, no side-effects were noted.Conclusion:Under the concept of "Zi Wu Liu Zhu", the administering of the medicine only in the morning or both morning and evening displayed similar results. Therefore it provided the basis for the reduction of the frequency of consuming the medicine. By applying the time administration of the medicine, it enhanced the compliance and medicinal effect on the patient. This method is thus effective and worth to be implemented clinically.
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