The Clinical Reserch With The Therapy Of TCM On Functional Dyspepsia

Objectives:To observe the gastric sensationthreshy and the changing scores of symptom scale of functional dyspepsia(FD),self-rating depression scale(SDS),self-rating anxiety scale(SAS),probe into the relationship between gaster sensor and FD of psychological factor by SAS and SDS,then evaluate objectively the clinical curative effect of @Tiaoxi Anshen decoction on the base of chaishao liujun decoction(CLD),which is my tutor's experiential prescription of TCM,and futher open up the new train of thought and method for the treatment of the functional dyspepsia(FD).Materials and Methods:To base on RomeⅢdiagnostic standard that agreed in meeting Rome in 2006,and refer to《diagnostic and therapeutical criterion of dyskinetic functional dyspepsia(FD) of TCM(draft)》compassed by the China Institute of TCM in 2001,we choosed 60 patients with FD(Gan-stagnation with Pi-deficiency type),who were divided into two groups at random.the treated group(30 cases) received CLD orally,a pouch everyday;the control group received @Tiaoxi Anshen decoction which is on the base of CLD orally,a pouch everyday,one therapeutic course of both groups was four weeks.Given patients the relevant explain of state of an illness in order to eliminate the doubt, but didn't give them mental consultation and treatment deeply.Then graded scores of symptom scale,SDS,SAS and water load test(The gastric sensationthreshy volunteers by water FD patients and 20 healthy volunteers by water load test.).before and after the course,analysed the statistics, observed the clinical effects,the changs between the dyspeptic symptom,gaster sensor and the psychological mental factors,ill-effects of the medicament and the rate of recrudescence four weeks after the treatment ended.Results:(1)Among the 60 patients with FD,the rate with depression was 31.7%,that with anxiety was 16.7%,while 7 patients contained both depression and anxiety,the total psychological abnormity was 36.7%statistics show;FD patients had significantly lower gastric sensation thresholby drinking water(435.0±55.9) ml vs(519.5±47.6) ml and(788.5±79.5) ml vs (1025.0±75.6) ml(p＜0.01),and compared with healthy people.So gastric hypersensitivity exists in FD patients;(2)The symptomatic scores of dyspepsia were positively correlated to the leves of SDS,SAS(r=0.370～0.444,p＜0.05～0.01);But 19 FD of depression,anxiety by SAS and SDS isn't related to gaster sensor(p＞0.1);(3) Before therapy,the state of illness between two groups could be compared with each other,the symptom of both groups alleviated obviously after treatment(p＜0.01),the therapeutic effects in every symptoms were similar except belch;the treated group was comparative with the control group in the total efficiency,but was superior in curable rate(p＜0.05);(4) After therapy,though the scores of the control group in indigestive symptom were declining apparently(p＜0.01),it were not be amended obviously in SDS,SAS and water load test; While the treated group show excellent efficience for the scores of syptoms,SDS,SAS and water load test;(5) After therapy,the relationships between the scores in indigestive symptom and SDS,SAS were both declined in the two groups,especially for the control group;As the period of treatment ended,the relationships between them turned to insignificant(p＞0.05);(6)The relievable rate of psychological abnormality and gastric sensation thresholby in the treated group was higher than the control group for the patients with FD;(7) During the therapy,in the control group one case catched tetter at the lower limbs after five days,two cases suffered from low-grade swirl after a week,but no ill-effects appeared in the treated group.Conclusions:(1)The rate of patients with FD and psychological abnormity was higher than patients with FD reported before,perhaps it has certain connection with TCM symptomatology (Gan-stagnation with Pi-deficiency type);(2)To patients with FD(Gan-stagnation with Pi-deficiency type),the relationships between occurance of the diseases,the grade of illness and the psychological factors were explicit,while therapy could affect them evidently;But the FD of depression,anxiety by SAS and SDS isn't related to gaster sensor(3) TLD could remarkably improve the clinical efficacy of treatment and the corresponding incidental psychological abnormity;(4)TLD and CLD hasn't obvious side-effect and ill-effect.