Expression Of PTEN And MMP-9, P27kip1 In Breast Cancer And Their Clinical Significance

Objective: To study the expression of PTEN, MMP-9 and P27kip1 in breast cancer and investigate their relationship and their clinical significance.Methods: To select 50 cases of breast cancer with complete clinical and pathological material treated from Jan. 2000 to Jun. 2001 and test the expression of PTEN, MMP-9, P27kip1 in breast cancer by the SP immunohisto-chemical method, and analyze the relationship of their expression and age, hormone receptor status, menopause status, clinical stage, axillary lymph node metastasis and prognosis.Results: The high expression rate of PTEN, MMP-9, P27kip1 are54%, 74%, 62% respectively. The expression level of PTEN was negatively correlated with histological grade, clinical stage and axillary lymph node metastasis(p<0.05), and it was positively correlated with ER level(p<0.05), but it has no correlation with age, menopause status, PR status. The expression level of MMP-9 was positively correlated with clinical stage, axillary lymph node metastasis (p<0.05), but it has no correlation with age, menopause status, histological grade, ER and PR status. The expression level of P27kip1 was negatively correlated with histological grade, clinical stage and axillary lymph node metastasis(p<0.05), and it was positively correlated with ER level(p<0.05), but it has no correlation with age, menopause status, PR status.Conclusion: The expression of PTEN, MMP-9, P27kip1 in breast cancer correlates with clinical stage and axillary lymph node metastasis and can be used as the marker of patient's prognosis. Detecting the expression of PTEN, MMP-9, P27kip1 has the referential significance with clinical gene-targeted therapy.