The Primary Study Of Breath Test In The Diagnosis Of Lung Cancer

Background and ObjectivesLung cancer is a kind of disease which strongly does harm to the health and lives of mankind.It's known that early diagnosis and early treatment of lung cancer can obviously improve prognosis of the patients.Breath test is a quite promising technique for early cancer detection,with the advantages of simplicity,non-invasion and safety.The study aims to clarify the characteristic volatile organic compounds(VOCs)in lung cancer patients' exhalant breath air,and to obtain the raw data for setting up a statistical model for the diagnosis of lung cancer.Materials and methodsIn this study 30 cases of lung cancer patients' exhalant breath air and 30 cases of healthy human's exhalant breath air were collected.The SPME(solid phase microextraction)-GC(gas chromatography)system was used to identify and quantify the VOCs in exhalant breath air.The characteristic VOCs were analysed by comparing the VOCs of lung cancer patients' with healthy human's.ResultsHeptanal was detected in 28 cases of lung cancer patients with different histo-pathological types,but in only one case of healthy human. The concentration of Haptanal had no statistical diffenence between adenocarcinoma and squamous carcinoma.There were 18 cases of methyl cyclopentane of all 30 cases of lung cancer patients and only 10 of 30 of healthy human.The concentration of methyl cyclopentane in both groups had no significant difference. ConclusionHeptanal was testified to be the biomarker of the VOCs in lung cancer patients.There was no evidence proved that Methyl-cyclopentane was the biomarker of the VOCs in lung cancer patients.