The Clinical Analysis Of 104 Young Women With Breast Cancer

Breast cancer is the main malignant tumors that endangeres the health of women. we have about 1.2 million women with a new risk of breast cancer each year,and nearly 500,000 people dieing of the disease. Of this century, the morbility of breast cancer worldwide each year to 0.2% -8% rate increase. Breast cancer occurs predilectionally in women from 40 to 60 years old. In recent years, the age of onset of breast cancer has advanced than before, we can find many young people with breast cancer in the clinic. Studies showed that young breast cancer (≤35 years) has unique clinic features and characteristics of molecular biology, pathology types are mainly invasion ductal carcinoma, invasive lobular carcinoma,at the same time, young breast cancer is easy to lymph node metastasis, estrogen and progesterone receptor-positive rate is low, epidermal growth factor positive rate is high。In order to further clarify young breast cancer clinical characteristics, we retrospectively analyzed 104 cases of youth (≤35 years old) breast Cancer patients from January 1999 to 2008 January in jilin university with ER and PR and C-erbB-2, tumor size, histological type, TNM stage, axillary lymph node metastasis, with the same period in the treatment of 801 elderly patients with breast cancer (> 35 years) the difference, and compare whether the differences between the two groups is statistically significant.104 cases of young breast cancer patients, the youngest is 19 years old, the average age is 31.5 years old, the incidence for the shortest time to visit was one day, the maximum was 72 months,and the average time was 6.25 months. In 801 cases of breast cancer in elderly patients , the greatest was 88-year-old, the average age was 50.73 years old, the incidence for the shortest time to visit one day, the maximum was 360 months, the average time was 11.37. According to the sixth edition of AJCC stage breast cancer clinical standards, youth group Phase I 18 (17.30%) cases, Phase II 42 (40.38%) patients Phase III 39 (37.50%) were stage IV 5 (4.82%) cases; T144 (42.31%) cases, T245 (43.26%) cases, T38 (7.69%) cases, T47 (6.74%) cases, N039 (37.50%) cases, N126 (25.00%) cases, N225 (24.04%) cases, N314 (13.46%) cases in the elderly group Phase I 201 (25.09%) cases, Phase II 362 (45.19%) cases, Phase III 209 (26.09%) were stage IV 29 (3.63%) cases; T1321 (40.07%) Cases, T2386 (48.19%) cases, T351 (6.37%) cases, T443 (5.37%) cases, N0407 (50.82%) cases, N1195 (24.34%) cases, N2124 (15.48%) cases, N375 (9.36%) patients . According to the 2000 China tumor classification criteria for pathological classification, the youth group of 104 patients with invasive ductal carcinoma of 89 (85.58%) cases of invasive lobular carcinoma (2.88%) cases, a simple carcinoma (0.96%) cases, intraductal Cancer 6 (5.77%) cases, 5 mucinous carcinoma (4.81%) patients in the older group of infiltrating ductal carcinoma 683 (85.27%) cases of invasive lobular carcinoma 11 (1.37%) cases, simple carcinoma 9 (1.12%) patients , ductal carcinoma in 50 (6.24%) cases of medullary carcinoma 12 (1.49%) cases, 20 mucinous carcinoma (2.49%) cases, Paget's disease 10 (1.25%) cases, hardware cancer (0.37%) cases. CONCISE STATISTICS 2000 using statistical software for window, two clinical indicators used twoχ2 test line single factor analysis and compare impact of age on clinical indicators. The results showed that the youth group in 104 cases of breast cancer cases are detected 40 cases of estrogen and progesterone receptor and epidermal growth factor expression, ER-positive rate was 72.50 percent (29/40), the PR-positive rate was 62.50% (25/40) , C-erbB-2 positive rate was 67.5% (27/40). 801 cases in the elderly group with 399 cases of breast cancer detected estrogen and progesterone receptor and epidermal growth factor expression, ER-positive rate was 72.43 percent (289 / 399), and PR-positive rate was 62.90% (251/399), C-erbB-2 positive rate was 28.5767.5% (114/399). Comparing the two groups, young breast cancer patients with an average attendance apparent as early as the time of old age group, youth groupⅢperiod incidence was significantly higher than that in old age group (P <0.05), while stageⅠ,Ⅱ,Ⅳh ad no significant difference (P > 0.05), but the youth group early (stageⅠ,Ⅱ) was significantly less than that in old age group, and the difference between the two groups was significant (P <0.05). there was no significant difference about tumor size between Youth group and elderly group (P> 0.05). And the lymph nodes results showed that the youth group lymph node metastasis was significantly higher than that of the elderly group, and the difference was significant (P <0.05), while the number of transfer had no statistical significance (P> 0.05). ER and PR receptor positive rate between Youth Group and the elderly grouphad no significant difference (P> 0.05), C-erbB-2 positive rate of the youth group were higher than those in the elderly group (P <0.05). Summing up the above, youth pathological types of breast cancer are invasion ductal carcinoma, invasive lobular carcinoma mainly .And young breast cancer also has following clinical features : easy lymph node metastasis, C-erbB-2 positive high rate, and late stage.