The Humeral Immunity Case-controled Study Of The Treatment With Broncho-Vaxom And Loratadine In The Children With The Recurrent Respiratory Tract Infection

objective:To explore the changes of humeral immunity and clinical therapy in children with recurrent respiratory tract infection(RRTI) given Broncho-Vaxom and Loratadine. Methods:240 cases of recurrent respiratory tract infection in children from our hospital were randomly divided into three groups.Questionnaires such as age,sexual,levels of disease and humeral immunoglobulin were unremarkable(chart 1,P＞0.05).Broncho-Vaxom group(group 1) was given 3.5mg Broncho-Vaxom during 10 consecutive days per month for 3 months,Loratadine group(group 2) was given Loratadine 5 or 10 mg during 12 consecutive days per month for 3 months,control group(group 3) was not given treatment with immunostimulatory,in cases infections episoded,each group was given basic therapy.The changes of humeral immunity in 3 months and times of clinical respiratory tract infection in 6 months were observed.Result:Serum IgG and IgA of group 1 or group 2 were significant difference compareing control group 3 before and after study respectively(chart 2,P＜0.01),and there was significant difference between group 1 and group 2 of humeral IgG and IgA(q=9.64,q=11.12,P＜0.01),group 1 is higher than group 2,but there was no significant difference among IgM of three groups (F=0.24,chart 8,P＞0.05),but in Broncho-Vaxom and Loratadine the effects of clinical were better than those of control group(q=8.06,q=6.78,P＜0.01).There was no significant difference between group 1 and group 2 of the effects of clinical(q=2.09, P＞0.05).Conclusion:The hypoimmuno-function is related to the children in RRTI, Broncho-Vaxom and Loratadine produce good curative effects on treating RRTI.They are should be treated in primary hospital by children with RRTI In order to avoid abuse antibiotics.