Changes Of Plasma Level And Clinical Significance Of BNP Before And After Stent Revascularization In Patients With Renal Artery Stenosis

Abstract: To investigate Changes of plasma level of BNP , blood pressure ,renal function and glomerular filtration rate (GFR)in patients with hypertension and significant renal artery stenosis before and after successful renal artery stent placement. The aim of the present study was to determine whether elevated BNP levels might predict which patients would have a renal artery stent placement.Methods:Percutaneous renal artery stent was performed in 26 patients with single or bilateral renal artery stenosis(≥70% ).The plasma level of BNP was measured before and after successful renal artery stent placement. All patients wrer underwent 2-10months clinical follow-up to observe the level of blood pressure , serum creatinine and GFR.Results:A total of 29 stents were placed successfully in 26 patients. BNP level was elevated (261.5±84.7pg/ml) before stent placement and decreased after 24 hours of the successful stent procedure (110.9±60.3pg/ml, P<0.01). The systolic and diastolic pressure were significantly decreased from 168.9±18.9 / 102.0±17.4 mmHg to 131.4±15.9 / 78.3±10.9 mmHg,(P<0.01).The serum creatinine level and glomerular filtration rate(GFR) did not change significantly during 2-10 months folow—up, (P>0.05)。However blood pressure in 5 patients with a baseline BNP≥330pg/ml in 26 patients (19.2%) was not well controlled,and GFR in 6 patients decreased and renal function deteriorated.Conclusions:BNP increased in patients with hypertension and renal artery stenosis and decreased after successful stent revascularization.Blood pressure and renal function were improved after placement of renal artery stent. In addition, baseline BNP level appears to be a good predictor of successful renal artery stent revascularization.