Changes And Meanings Of IL-6,IL-8,IL-10 In Blood And Bronchoalveolar Lavage Fluid In Patients With Severe Pneumonia

PartⅠThe dynamic changes of IL-6,IL-8,IL-10 in blood and bronchoalveolar lavage fluid in patients with severe pneumonia and their relation with prognosisObjective To study the dynamic changes characteristic of pro-inflammation interleukin-6 (IL-6),interleukin-8(IL-8) and anti-inflammation interleukin-10(IL-10) in blood and in bronchoalveolar lavage fluid (BALF) in patients with severe pneumonia and their relation with the severity of sickness and prognosis.Methods All patients were allocated into two groups according to the outcome of patients in the end of 10 days: favorable and unfavorable groups, Unfavorable groups including death patients. IL-6,IL-8and IL-10 were measured in system (blood) and local (BALF) in patients on days 1,4,7, We compared their different changes in the two different groups. In the other hand, we devided patients into two groups according to Clinical Pulmonary Infection Score (CPIS )which was recorded on day 1, CPIS > 6 group and CPIS≤6 group,Compare IL-6,IL-8 and IL-10 levels in blood and BALF between these two groups.Results IL-6 and IL-8 levels have similar tendency in blood and in the BALF in favorable and unfavorable groups,which all decreased in two groups. The tendency of IL-10 level decrease in favorable group, but increased in unfavorable group. IL-8 and IL-10 levels in blood and BALF were significant higher in favorable group than in unfavorable group in the same day(P<0.05). IL-6 level has no significant difference between these two groups(P>0.05).IL-6 and IL-8 levels in blood and BALF were significant higher in CPIS>6 group than in CPIS≤6 group. IL-10 level have no significant difference between these two groups. IL-6,IL-8 levels have obviously relativity with CPIS in blood and BALF respectively(P<0.05). IL-10 has no relativety with CPIS.Conclusion IL-6 and IL-8 levels in blood and BALF could reflect the severity of sickness. IL-8 and IL-10 levels in blood and BAL fluid could predict the prognosis of patients with severe pneumonia.PartⅡComparison of IL-6,IL-8 and IL-10 in bronchoalveolar lavage fluid between involved and uninvolved lung in patients with severe unilateral pneumoniaObjective To study pro-inflammation interleukin-6 (IL-6),interleukin-8 (IL-8) and anti-inflammation interleukin-10 (IL-10) levers in bronchoalveolar lavage fluid (BALF) between involved and uninvolved lung in patients with severe unilateral pneumonia.Methods We prospectively studied 25 patients with severe unilateral pneumonia, IL-6,IL-8 and IL-10 levels were measured in bronchoalveolar lavage fluid of two sides lung with 24 hours by radioimmunology assay after final diagnosis, and contrast groups with no lung infection do that in suitable time.Results IL-6,IL-8 and IL-10 levels in BALF were found to be significantly higher in the involved lung than those in the uninvolved lung (P<0.01) and which were higher in both sides in patients with severe unilateral pneumonia than contrast groups (P<0.01).Conclusion IL-6,IL-8 and IL-10 all participated the local inflammatory reaction in patients with severe pneumonia ,not only in involved lung but also in uninvolved one. The inflammatory response was more severe in the involved lung than in the uninvolved lung.