Clinical Study On YueXin Pill For Treating Angina Pectoris Of CHD

Objectives: To observe efficacy and adverse effects of YueXin Pill for Treating Angina Pectoris of syndrome of qi with blood stasis on clinical symptoms of TCM syndrome and taking Diaoxinxuekang capsule as the control,to objectively evaluate the efficacy and safety of YueXin Pill for treating angina pectoris CHD. Patients and methods: sixty patients with angina pectoris of syndrome of deficiency of qi with blood stasis entered the study and were randomized to treatment and control groups,30cases in each. The treatment group was given YueXin Pill,two pills one time and three times each day.The control was given Diaoxinxuekang capsule,two pills one time and three times each day.The treatment duration was four weeks. The study was made as a randomized double blind control trial. The dynamic electrocardiography(DCG)doppler echocardiography, electrocardiogram(ECG),the conditions of blood, urine,excrement,the liver and renal functions and blood liquid were determined at the beginning and the end of the trial respectively. During treatment,we observed the attack frequency of angina pectoris,reduction and stop with quick-acting dilated arteria coronaria medicine,the changes on TCM syndrome and the level of blood pressure and heart rate. The clinical treating effects and their beginning and maintaining time were assessed with the methods of grade score and described in words. The adverse effects were illustrated in words. Results: There was very significant efficacy on treatment and control groups for treating angina pectoris of CHD(P<0.01) .they were equivalent efficacy and had no significant difference(P>0.05).but there was significant difference between the control an treament groups(P<0.05).Two groups had obvious effect on attending blood liquid(P<0.05),but treatment group was better than control group in reducing TC(P<0.05).Two groups had obvious effect on reducing blood pressure and slowing heart rate(P<0.05) and no significant difference each other(P>0.05).Treatment group had significant effect on perfecting hemorheology and reducing platelet aggregating rate and was better than control group(P<0.05).The "three great regular tests" ,liver and renal functions had no marked changes during the treatment. There were no adverse effects in both groups after taking the drugs.