Study On The Prognosis Of Patients With Coronary Heart Disease With Qi Deficiency And Blood Stasis Treated By Drug Balloon Combined With Qishen Yiqi Dropping Pill

Objective: We observed the improvement of angina pectoris,TCM symptoms,cardiac function,small vessel lesions,incidence of adverse cardiovascular events,and rehospitalization rate in patients with coronary artery disease qi deficiency and blood stasis type by combining drug balloon with Qishen Yiqi Dripping Pill,and evaluated the efficacy and prognostic value of drug balloon combined with Qishen Yiqi Dripping Pill in these patients to provide a scientific and reliable theoretical basis for the clinical treatment of patients with coronary artery disease qi deficiency and blood stasis type.Methods: Sixty-four patients with small-vessel lesions of qi deficiency and blood stasis type coronary artery disease treated by drug balloon were included,and they were divided into 32 cases in the control group and 32 cases in the test group,and the control group was treated with western drugs,and the test group was treated with Qishen Yiqi Drops combination for 9 months on the basis of the control group.The indexes of the subjects in the two groups were collected before treatment,after 1 month of treatment,after 3 months,after 6 months and after 9 months,respectively.The quality of life of the subjects was assessed by the Seattle Angina Scale;the degree of improvement of the subjects’ symptoms was assessed by the total TCM symptom score,individual TCM symptom scores and TCM symptom efficacy;the cardiac function of the subjects was assessed by the left ventricular ejection fraction;the degree of residual stenosis and net increase in lumen diameter of the diseased vessels were used to assess the subjects’ small coronary artery lesions;the subjects’ prognosis was assessed by the incidence of major adverse cardiovascular events and rehospitalization rates over 9 months combined with the above observations.Results: 1.Seattle Angina Scale:(1)Intra-group comparison: After 1month of treatment,there was no statistical difference in the degree of somatic limitation between the subjects in both groups compared with that before treatment(P > 0.05);the subjects in both groups showed statistical differences in the stable status of angina pectoris,angina attack,treatment satisfaction,and disease awareness compared with that before treatment(P < 0.05).After 3 months,6 months,and 9 months of treatment,all 5 dimensions of the Seattle Angina Scale improved in subjects in both groups compared to those before treatment,with statistical differences(P < 0.05).(2)Comparison between groups:compared with the control group,after 1 month of treatment,there was no statistical difference in all 5 dimensions of the Seattle Angina Scale in the test group(P > 0.05);after 3 months,6 months and 9 months of treatment,there was no statistical difference in the degree of treatment satisfaction and disease awareness between the two groups of subjects(P > 0.05),and the experimental group was better than the control group in improving the degree of somatic limitation,angina pectoris stability and angina attacks of the subjects,with statistical differences(P < 0.05).2.Total TCM symptom scores:(1)intra-group comparison: after 1month,3 months,6 months and 9 months of treatment,total TCM symptom scores of subjects in both groups were lower than those before treatment,with statistical differences(P < 0.05);(2)inter-group comparison: after 1 month of treatment,total TCM symptom scores of subjects in the experimental group were not significantly different from those in the control group(P > 0.05);after 3 months,6 months and 9months of treatment,total TCM symptom scores of subjects in the test group were lower compared with the control group,with statistical differences(P < 0.05).3.Chinese medicine symptom efficacy: After 9 months of treatment,there was no statistical difference in the total effective rate of Chinese medicine symptoms in the test group compared with the control group(P > 0.05).4.Single TCM symptom scores:(1)Intra-group comparison: After 9months of treatment,the single TCM symptom scores of subjects in both groups were lower than those before treatment,with statistical differences(P < 0.05).(2)Comparison between groups: After 9 months of treatment,the test group was significantly better than the control group in improving chest tightness,palpitation and sweating,fatigue and shortness of breath,with statistical differences(P < 0.05);there was no statistical difference between the test group and the control group in improving chest pain and purple complexion(P > 0.05).5.Cardiac function indexes: After 9 months of treatment,there was no statistical difference in the left ventricular ejection fraction of the control group compared with that before treatment(P>0.05),while the left ventricular ejection fraction of the test group improved significantly compared with that before treatment,with statistical difference(P<0.05).The test group was better than the control group in improving the left ventricular ejection fraction of the subjects,and there was a statistical difference(P < 0.05).6.Coronary small vessel lesions: After 9 months of treatment,the residual stenosis at the coronary small vessel lesion site in the control group was significantly larger than that in the immediate postoperative period,which was statistically significant(P < 0.05);the residual stenosis at the coronary small vessel lesion site in the test group was not statistically different from that in the immediate postoperative period(P >0.05),and the residual stenosis at the coronary small vessel lesion site in the test group was smaller than that in the control group There was a statistically significant difference(P < 0.05);the net increase in lumen diameter at the coronary small vessel lesion site in the test group was greater than that in the control group,and there was a statistically significant difference(P < 0.05).7.Endpoint events: At 9 months of treatment,the incidence of major cardiovascular adverse events was not statistically different in the trial group compared to the control group(P > 0.05);subjects in the trial group had a statistically lower readmission rate than the control group(P <0.05).Conclusion: The drug balloon combined with Qishen Yiqi Drops can better improve angina attack,Chinese medicine symptoms,and cardiac function in patients with qi deficiency and blood stasis type coronary heart disease;improve the degree of stenosis of small coronary artery lesions;reduce the re-hospitalization rate of patients,improve their quality of life,and improve their prognosis.