The Study Of The Effects And Mechanisms Of Combining Cupping And Acupoint-Plastering Treatment On Bronchial Asthma Of Non-Acute Attack

Background: Bronchial asthma is one kind of common and requently encountered disease which is an air passage's chronic inflammation caused by the inflammatory cell. Inflammation makes the susc airway hyperreactivity to the provocative factor, and that causes the hydrosarca and coarctation of air passage. Clinically appearance is expiratory dyspnea chest distress cough and so on.Asthma commonly divice to acute episode period and non-acute episode period. In period of acute episode, the main cure is to relieve airway obstruction, to retrieve the hypoxemia, and to recuperate the pulmonary function, in case of aggravation and complication. In period of non-acute episode, we must formulate a long term therapy to prevent the acute episode, for the existence of chronic inflammation. Therefore, in modern medicine, the main cure is to prevent from the metabola metamorphosis source, to use theolix,β-receptor agonist, a-receptor agonist, cholinergic receptor antagonist, H₁-receptor antagonist and glucocorticoid for dilating bronchus ,promoting ciliary motion and inhibiting the tacho-generate or tardive generate. But the theocine alike drugs in blood ,which easily cause toxic reaction, are at a instability level and in a narrow margin of safety. The hormone alike drugs also cause lots of adverse reaction. Considering the adverse reaction of western medicine, imploring a safe and effective therapy direct the traditional Chinese medicine's investigation. Asthma belongs to the "the syndrome of dyspnea" or "the syndrome of bronchial wheezing" or "the syndrome of cough". The etiopathogenisis of asthma is caused by the three of flollowing: blocking of Qi, suffering the untimely disease, obstructing by the phlegm. In , there were recorded "the syndrome of wheeze" and "the syndrome of upbearing Qi. Zhu danxi first initiated the name of "asthma". In the period of Ming, Yubo pointed out the difference between bronchial wheezing and wheezing, which caused by the latent phlegm retaining in the lung.In modern times, the traditional Chinese medicine theory consider that the asthma is asthenia in origin and asthenia in superficiality. The wind, the cold, the congestion,the Qi or mix of them, relieve the the phlegm to cause the asthma. Deficiency of lung, spleen and kidney is the original deficiency. Insufficiency of lung-Qi for a long time would involve the spleen and kidney, following the weakness of respiratory function. Usually in the period of onset, asthma appearance is state of evil domination, while appearance is asthenia of healthy energy in the period of catabasis.Relieving cough and reducing sputum, reinforcing the lung, invigorating the spleen, tonifying kidney are the main therapeutics of TCM. Aiding the external treatment such as ventouse, point application, injectio ad acumen, acupuncture, ultrasonic atomizing inhalation, ultrashort wave treament, massage, can effectually prevent the asthma.Objectives : To observe the effects of combining cupping and acupoint-plastering treatment on the changes of pulmonary-function, immunoglobulin, T-lymphocyte Sub-populations. To analysis the effects and mechanisms of combining cupping and acupoint-plastering on treatment of bronchial asthma of non-acute attack.Methods: Patients were divided into two groups randomly: 30 cases in control group and 60 cases in treatment group. Liu-wei-di-huang pill and Yu-ping-feng powder were applied to each group while the treatment group were given cupping combined with acupoint-plastering additionally. All treatments persisted for 3 cycles, each cycle include 30 days. The symptoms (cough and expectoration) and sign (wheeze) were observed and pulmonary-function (MMV, FEV_1.0, FVC, FEV_1.0%), levels of immunoglobulin (IgA, IgG, IgM, C₃ and C₄) and T-lymphocyte subpopulations (CD₄, CDs, CD₄/CD₈ ratio) were measured.Results: Cupping combined with acupoint-plastering significantly improved bronchial asthma of non-acute attack, the total efficiency rate was 93.33% in the treatment group comparing with 86.67% in the control group (P<0.05). The symptoms such as cough, expectoration, asthma and wheeze were ameliorated and the quality of life were enhanced in treating group when compared with control group (P<0.05). The level of MMV, FEV_1.0, FVC, , IgA, IgG, IgM, CD₃ and CD₄ were improved respectively and the level of CD8 were decreased in treating group when compared with the control group (P<0.05).Conclusions: Our study showed that combined cupping and acupoint-plastering could alleviate inflammation and ameliorate symptoms of asthma of non-acute attack. The effects of cupping combined with acupoint-plastering might come from regulating the cell immunity and improving the pulmonary-function. Our study hints that it is worthy of further investigation on the mechanism of combining cupping and acupoint-plastering on treatment of bronchial asthma of non-acute attack.