The Preliminary Analysis On The Risk Factors And Mechanisms Of Type 2 Diabetes With Depression

Objective To study the prevalence of depression in hospital type 2 diabetes patients ;to analyze the risk factors in type 2 diabetes with depression.Methods (1)We conducted 86 hospital patients of type 2 diabetes [male 48,female 38]. The experimenters finished the assessment of the Zung's self-rating depression scale (SDS) by the special messengers. The index of the depression severity was calculated by the score of the Zung's self-rating depression scale (SDS).Depression was defined when the index of the depression severity was more than 0.5. (2)Through inquiring the case history and laboratory examination,we assayed BMI,FBG,PBS2h, HbA1c,TG,CH,FIB, UAER and the number of chronic diabetic complications. Calculate the prevalence of depression in different groups of sex,age,the years of educated, BMI,duration,the number of chronic diabetic complications,weather or not injecting insulin ,FBG, PBS2h, HbA1c,TG,CH,FIB,UAER. (3) We analysised the risk factors of depression by the unconditional Logistic regression equation,using the index of the depression severity(Y=0,1)as dependent variable and sex,age,the years of educated, BMI,duration,the number of chronic diabetic complications,weather or not injecting insulin ,FBG, PBS2h, HbA1c,TG,CH,FIB,UAER as independent variable.Results (1)40 of 86 hospital type 2 diabetes patients had depression. (2)The contrast of the prevalence of depression in different groups of duration, the number of chronic diabetic complications,weather or not injecting insulin,FBG, HbA1cwere significant(p<0.05). (3) The unconditional univariate Logistic regression equation show that the number of chronic diabetic complications ,weather or not injecting insulin,FBG,HbA1c were correlation with the index of the depression severity.The unconditional multivariate Logistic regression equation show that the number of chronic diabetic complications ,weather or not injecting insulin were correlation with the index of the depression severity.Conclusion The prevalence of depression in hospital type 2 diabetes patients is 46.5%. The number of chronic diabetic complications ,weather or not injecting insulin are independent risk factors of depression. Objective To study the change of cortisol in the patients of diabetes mellitus with depression.Methods (1)The experimenters were divided into four groups by the glucose and the score of the self-rating depression scale.There are the group without diabetes or depression (control group) ,depression group without diabetes,diabetes group without depression and diabetes group with depression.Each group had 20 experimenters.(2)Every experimenter measured the waist circumference and the waist-to-hipratio.The level of cortisol (8Am,4Pm,0Am) were measured,and by the three level we calculated the average cortisol level of 24 hours.The levels of the blood sugar,TG,CH were measured.(3) The experimenters finished the assessment of the Zung's self-rating depression scale (SDS) by the special messengers'assisting.The index of the depression severity was calculated by the score of SDS.Results (1) Compared with the control group, the cortisol of 8Am and the average level in the other three groups elevated significantly(P<0.01). Compared with depression group without diabetes , the cortisol of 4Pm, 0Am and the average level in the diabetes group with depression elevated significantly(P<0.05). Compared with diabetes group without depression , the cortisol of 4Pm, and the average level in the diabetes group with depression elevated significantly(P<0.05). (2) The index of the depression severity in diabetes group without depression is significantly higher than that of the control group (P=0.001).That of the group of diabetes with depression is slightly higher than that of depression group without diabetes, but had no significance. (3) Multiple linear regression analysis showed that the index of depression severity was positive correlation with the average level of cortisol,age and was negative correlation with the waist circumference. The index of depression severity wasn't correlation with the level of the blood sugar,TG,CH.Conclusion Diabetes and depression correlation with the elevation of the cortisol level.The level of cortisol in diabetes group with depression elevate more significantly.The index of depression severity is positive correlation with the average level of cortisol in 24h.