The Study On The Influence Of Busuishengxue Granule To Blood IL-10 Receptor In Myelodyplastic Syndrome-Refractory Anemia

Objective: To observe the clinical effect of Busui Shengxue granule(BSSXG) in treating Myelodyplastic Syndrome-Refractory Anemia(MDS-RA),evaluate the expression of the blood IL-10 before and after treatment, and reveal the pathogenesis of MDS-RA and effect mecheanism of supplement BSSXG on MDS-RA.Methods: Forty cases of MDS-RA were divided into two groups, twenty-five patients of experiment group were treated with BSSXG and fifteen of control were treated with ATRA. We observed the clinical effect of these forty patients treated with two groups. We explored ELISA to detect forty patients the expression of the blood IL-10 before and after treatment.Results: 1.BSSXG to MDS-RA can effectively improve anemia and hemorrhage symptom, and peripheral blood and so on, discrease immature cells in peripheral blood and bone marrow, it make sick hematopoietic conversion to normal hematopoietic, and there is no differences between the experiment group and the control group(P>0.05). 2.The expression level of blood IL-10 in MDS patients was high, after treatment the expression level was descended(P<0.05).Conclusion: 1.The effect of BSSXG was smilar to ATRA, it proves that it has the certainly good curative effect to treat MDS-RA; 2.There was abnormal expression of the blood IL-10 in MDS-RA patients, BSSXG can lower the level of IL-10, it demonstrats that BSSXG is one of treating MDS-RA mechanisms.