Anti-tumor Effects Of The Combination Of Honokiol And Paclitaxel In Mice Lewis Lung Cancer In Vivo

The honokiol is e extrated from the Chinese medicinal materials magnolia bark, honokiol belongs to the phenolic compounds that it has allyl grounp. The main active component of magnolia bark is honokiol. honokiol has been found having a variety of pharmacologicaleffects, such as anti-inflammatory, antithrombotic, anti-arrhythmic, antioxidative and anxiolytic effects.one of the pharmacological action is antitumor action . The main mechanism of anticancer is that honokiol can induce apoptosis and antiangiogenesis,The mechanism of paclitaxel is distinctive ,Paclitaxe can bind with microtubule,it can promote microtubule binding and suppress microtubule disaggregation on the point of attachment point, Paclitaxel can interfere karyokinetic division of the tumor cell through interrupt depolymerize.it can suppress tumor cell proliferation through arrest of cell cycle at G2 /M stage.in addition ,the anticancer action of paclitaxel relates with inducing tumor cell apoptosis..Low dose paclitaxel has the actioning of antiangiogenesis. two kinds of drug have different pharmacal mechanism of action. We assume it is probably better that combine two kinds of drug than single. We culture lewis lung cancer cell in vitro,we raise model of lewis...