The Relationship Between OPRM1 Gene A118G Polymorphism And Alcoholic Liver Disease, Alcohol-dependent In Korean And Han Men Of Yanbian Area In China

[Objective] To investigate the relationship between the frequencies of OPRM1 (m-u-opioid receptor) gene A118G genotype, allele and alcohol liver disease(ALD), alcohol-dependent in Korean and Han men of Yanbian area in China.[Methods] Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect OPRMl gene A118G single nucleotide polymorphism in ALD group(n=109), alcohol-dependent group(n=103) and health control group(n=95) in Korean and Han men of Yanbian area. We calculated and compared the genotype and allele frequencies in three groups.[Results] In Korean men, the frequency of genotype GG was 0.071 in the ALD group; the frequencies of genotype GG in the alcohol-dependent and health control groups were 0.086 and 0.04. The frequencies of the G allele were 0.196, 0.190 and 0.130 in the ALD group, alcohol-dependent and health control groups respectively. There was no significant difference of frequencies distribution of OPRMl gene A118G polymorphism among these three groups(P>0.05).In Han men, the frequency of genotype GG was 0.038 in the ALD group; the frequencies of genotype GG in the alcohol-dependent and health control groups were 0.022 and 0. The frequencies of the G allele were 0.142,0.144 and 0.133 in the ALD group, alcohol-dependent and health control groups respectively. There was no significant difference of frequencies distribution of OPRMl gene A118G polymorphis-...