Hypoglycemic Effect Of Gastric Bypass In Diabetic Rats And The Role Of Glucagon-Like Peptide-1

Objective To study the hypoglycemic effect of Gastric bypass (GBP) in streptozotocin(STZ)-induced nonobese diabetic rats and evaluate the role of glucagon-like peptide-1 ,weight loss and decreased food intake after operation.Methods thirty-two male SD diabetic rats induced by STZ were randomly allocated into four groups: GBP(group O), shame operation(group S), food restriction (group F) and controls (group C). Plasma glucose concentration, insulin, glucagon-like peptide 1 (GLP-1) were measured respectively at fasting and postprandial condition before and the 1st week, 2nd week, 3rd week, 4th week, 8th week after GBP in all rats, weight and food intake were measured simultaneity.Results 3 weeks after operation in the GBP rats , mean fasting plasma glucose concentration declined from (16.84±3.82) mmol/L to (13.24±3.53) mmol/L and postprandia plasma glucose from (31.88±6.22) mmol/L to (17.35±3.47)mmol/L ( p<0.05 ) , fasting plasma insulin concentration rose from (28.66±8.17)IU/L to (46.48±10.41)IU/L and postprandia plasma insulin from (30.73±8.99)IU/L to (51.14±11.45)IU/L...