The Change Of Glucose Tolerance And GLP-1in GK Rats After Gastric Bypass Surgery

ObjectiveDiabetes is one of the major chronic diseases of serious harm to humanhealth, Recent studies found that gastric bypass surgery(GBP) exact treatmentof type2diabetes(Type2diabetes mellitus,T2DM),But the mechanism is notfully understood, including the mechanism of gastrointestinal neuroendocrinehormones that regulate islet function has become a hot research field of surgicaltreatment of diabetes. This article selection of non-obese type2diabeticanimal-GK rats, set up to retain full stomach, small intestine section bypass GBPanimal models, the exact site of bypass effect, intestinal source of endocrinehormones-glucagon-like peptide-1(GLP-1)expression changes in the law andpostoperative changes in blood sugar.Methods30male GK rats were randomly Divided into5groups：group I (shamegroup), group Ⅱ (tradition Bypass), group Ⅲ (duodenal bypass)， group Ⅳ(duodenal-jejunal bypass)， group Ⅴ (duodenal-ileal-bypass)． OGTT wereperformed before and fourth weeks after surgery and GLP-1was determined.ResultsCompared with group I, The OGTT blood glucose values dropped obviouslyat each time points after surgery. Compared with groupsⅡ, Ⅲ,ⅣandⅤare notsignificant changes in fasting blood glucose level after surgery decreasedsignificantly. GLP-1increased after surgery, especially in groupⅤ. Conclusions1：GBP is an effective method to cure the T2DM2：The effect of gastric bypass on blood glucose happens in ileum.3：The improvement of glucose metabolism is associated with the increaseof GLP-1．...