Experimental Study On Nux-Vomica Decoction For Treating Primary Hepatic Carcinoma

Objective:To evaluate the clinical effect of nux-vomica decoction(NVD)to primary hepatic carcinoma (PHC) by animal experiment study, and discuss the related mechnism, so as to provide sentific. foundation to the clinical appliance.Methods: 125 male KM mice were used in the experiment, 75 mice of which were injected S₁₈₀ tumor cells and the others were injected H₂₂ tumor cells. S₁₈₀-bearing mice and H₂₂-bearing mice were respectively divided into 5 groups: the pathological model group, NVD low, middle, high dose treatment groups and the western medicine group(5-Fu). From the next day, the groups were treated by NVD low, middle and high dose and 5-Fu respectively, the pathological model group was given distilled water with the same dosage, once daily for 7 days. After 7 days, S₁₈₀-bearing mice were killed and weighed. Spleens, thymuses and tumors were excavated and weighed. Count The inhibition rates, the indexs of spleens and thymuses, and observe the pathogenic changes of tumor cells, the survival time of H₂₂-bearing mice, and count the life prolonging rate.Result:The result of experiment indicated that (1)The inhibition rates of NVD on S₁₈₀ were significantly higher than the pathological model control group (P<0.01).(2) The survival time of the mice treated by NVD on H₂₂ was distinctly longer than the pathological model controlling group (P<0.01).(3) Compared with the pathological model controlling group, NVD high and middle dosages significently increased the indexs of the spleens and thymuses(P<0.05). NVD low dosage did't have the obvious effect (P > 0.05). While 5-Fu and western medicine had the obvious descending effect on them(P<0.01).(4)All treatment groups coulddiminish tumor cells and make some tumor cells disappear.Conclusion: These results suggest that nux vomica decoction can inhibit the growth of hepatic carcinoma cells in vivo, enhance the quality of life, prolong the survival time and strengthen immune function.The effect might be related with improving the immunity function and inducing the apoptosis of tumor cells.