Clinical Use Of Noninvasive Measurements Of Airway Inflammation With Inhaled Corticosteroid With Long-time Remission With Asthma In Children.

Background: Management of pediatric asthma is currently based on symptoms and lung function, but symptoms are often inaccurate and often a second-hand report from parents, spirometry depends on the cooperation of children, sometimes is within the normal range in symptomatic children. Children experienced loss of asthma control despite fulfilling these clinical criteria. Recently a number of noninvasive methods to assess inflammation have been developed in an effort to optimize anti-inflammatory treatment.Objectives: We studied asthmatic children who were in a long-term remission more than 12 months (to abbreviate with long-term remission), Lung function parameter, the airway responsiveness(AHR) and eosinophil count (EOS%) in SI(sputum induced), eosinophil cationic protein(ECP) and interleukin-5(IL-5) both with the SI and blood serum were measured in order to investigate the use of noninvasive methods of monitoring airway inflammation and in optimizing treatment in children with asthma.Methods: We studied 13 asthmatic children who were in a long-term remission, 15 children with asthmatic remission less than twelve months (to abbreviate with short-term remission), 17 children with exacerbated asthmatics (EA) and 12 healthy control students (HC). Lung function were measured with tradition method, AHR were measured by methacholine provocation test, collecting the SI and blood serum, SI samples analyzed for EOS%, ECP and IL-5 both with the SI and blood surum were measured. Compare with the variations in the groups. Statistical analysis was performed by using rank sum test, Chi-square or one-way factorial ANOVA. Correlations were measured using Spearman rank correlation. Predictors of long-term remission was sought...