Epidemiologic Survey On The Helicobacter Pylori Infection In Type 2 Diabetics And Association With Complications

PART â… Investigation of Helicobacter Pylori Infection in Type 2 Diabetic Patientsand Relations of Infection with Upper-Gastrointestinal Tract Symptoms .Objective: To investigate the prevalence of helicobacter pylori(H.pylori)in type two diabetics, and the relations of infection with upper gastrointestinaltract symptoms and endoscopic feactures, observe efficacy of triple therapy.Methods: A parallel-controlled study was conducted between 125 type 2diabetics and 125 nondiabetics without gastric disease in digest clinic. All thepatients had dyspeptic symptoms and gastroscopy ,serum antibody,rapid ureasetest and 14C-UBT examination were performed to diagnose H.pylori infection ,upper gastrointestinal symptoms and diabetic duration were noted in detail,upper gastrointestinal tract perspective after barium strip by mouth was neededto diagnose gastroparesis in diabetics. All patients affected by H.pylori receivedthe same triple therapy for 1 week, 4 weeks later after therapy, recheck14C-UBT to investigate the eradication rates of H.pylori. Results: Thedifference of H.pylori prevalence between diabetics and controls was notsignificant(p>0.05), but the diabetics with gastroparesis had a higher incidenceof H.pylori than those without gastroparesis and controls, the difference wassignificant (p<0.05);The infection rate of different age stages had notsignificant difference between diabetics and controls;The infection rate had anincreased tendency with diabetic duration;The incidence of early satiety,nausea,distention,superior belly pain were higher in diabetics affected byH.pylori than those were not affected (p<0.05);The incidence of early satietyand distention was higher in diabetics with gastroparesis and H.pylori infectionthan other groups(p<0.01);The eradication rate of H.pylori in diabetics waslower than in controls, there was a significant difference between the twogroups(p<0.05).Conclusion: The infection of H.pylori may be associated withgastroparesis in diabetics. The infection rate had an increased tendency withdiabetic duration. Upper gastrointestinal tract symptoms in diabetics may beassociated with H.pylori infection, eradication of H.pylori may be helpful toimprove these symptoms, but the eradication rate of H.pylori is lower indiabetics than in nondiabetics.PART â…¡Association of Helicobacter Pylori Infection with Blood fat,Reactants ofInflammation in Peripheral Blood and Common Complications in Type 2DiabeticsObjective: To investigate the association of helicobacter pylori(H.pylori) infection with blood fat,reactants of inflammation in peripheralblood and common complications in type 2 diabetics. Methods: Chose 116type 2 diabetics in endocrine ward, Collecting vein anticoagulated blood plasmaand reserved in frozen in order to check H.pylori antibody,fibrinogen and CRPafterward. According clinical data conducted a retrospective study. Diabeticduration,smoking,drinking,inhabited environment,body weight,body height,blood pressure in quiescent condition , biochemical indicators andcomplications such as coronary heart disease,cerebrovasular disease wererecorded. Divided the diabetics into 2 groups by whether affected by H.pyloriand then performed a contrast study. Results: Alterations in the levels offollowing serum lipid were significantly more profound in H.pylori positivediabetics: High triglycerides(p<0.01)and low HDL cholesterol(p<0.05).Thelevels of reactants of inflammation such as WBC,PLT,Fg,CRP were nostatistically significant difference between the two groups;Coronary heartdisease and cerebrovascular disease were more prevalent in diabetics with thanwithout H.pylori infection(p<0.05),there was a significant difference,Othercomplications were no differently distributed. Conclusion: H.pylori infectionmay be one of causative factors of Coronary heart disease and cerebrovasculardisease in diabetics. The mechanism of H.pylori on Coronary heart disease andcerebrovascular disease in diabetics may be related with the affection ofH.pylori to lipid metabolism. The effect of H.pylori to reactants ofinflammation in peripheral blood is not obvious in diabetics.